Results 81 to 90 of about 2,123,623 (331)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Using Downstream DPSK and Upstream Wavelength-Shifted ASK for Rayleigh Backscattering Mitigation in TDM-PON to WDM-PON Migration Scheme

IEEE Photonics Journal, 2013
A migration scheme from time-division-multiplex passive optical network (TDM-PON) to wavelength-division-multiplex PON (WDM-PON) using differential phase-shift keying (DPSK) for the downstream signal and wavelength-shifted amplitude-shift keying (WS-ASK)
C. W. Chow, C. H. Yeh
doaj   +1 more source

Run‐of‐river dams as a barrier to the movement of a stream‐dwelling amphibian

Ecosphere, 2020
Human activities frequently create structures that alter the connectivity among habitats or act as barriers to the natural movement of animals. Movement allows individuals to access different habitats, connect life history stages, and maintain genetic ...
Griffin C. Dare, Rylee G. Murray, Danielle M. M. Courcelles, Joshua M. Malt, Wendy J. Palen   +4 more
doaj   +1 more source

Granulocyte Colony-Stimulating Factor Mediated Regulation of Early Myeloid Cells in Zebrafish

Frontiers in Bioscience-Landmark, 2022
Background: Colony-stimulating factor 3 (CSF3), more commonly known as granulocyte colony-stimulating factor (G-CSF), acts via a specific cell surface receptor CSF3R (or G-CSFR) to regulate hematopoiesis, with a particularly key role in the myeloid cell ...
Anna B. Meier, Faiza Basheer, Robert Sertori, Miranda Laird, Clifford Liongue, Alister C. Ward   +5 more
doaj   +1 more source

Observations on the downstream movements of brown trout fry (Salmo trutta L.)in the Lissuraga [Translation from: Bulletin Francais de la Pisciculture No.274 1-17, 1979] [PDF]

, 1980
The phenomenon of the downstream movement of brown trout fry has been noticed for a very long time by fish biologists. The work presented here, and taking place in the framework of the hydrobiological research of the INRA, represents the results of three
Cuinat, R., Heland, M.
core  

Hydrological controls on river network connectivity [PDF]

, 2019
This study proposes a probabilistic approach for the quantitative assessment of reach- and network-scale hydrological connectivity as dictated by river flow space–time variability. Spatial dynamics of daily streamflows are estimated based on climatic and
Botter, Gianluca, Celegon, Elisa Alessi, Fanton, Pietro, Garbin, Silvia   +3 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Environmental determinism of year to year recruitment variability of European eel in a small coastal catchment, the Frémur river, north-west France [PDF]

, 2009
The influence of environmental factors (mainly the river flow) on the year-to-year variability of European eel Anguilla anguilla fluvial recruitment in a small coastal River (north-west France) was examined.
Acou, Alcobendas, Barbin, Bardonnet, Birrel, Briand, Briand, Cargnelli, Casselman, Chen, Ciccotti, Ciccotti, Creutzberg, Daverat, Desaunay, Dutil, Edeline, Edeline, Edeline, Elie, Elie, Feunteun, Feunteun, Gandolfi, Gascuel, Gascuel, Hoyle, Ibbotson, Imbert, Jellyman, Jessop, Jonsson, Kettle, Knights, Laffaille, Laffaille, Laffaille, Laffaille, Legault, Legault, Martin, McCleave, McGovern, McKinnon, Moriarty, Mounaix, Naismith, Parsons, Ringuet, Sloane, Sorensen, Sorensen, Sorensen, Sullivan, Tesch, Tongiorgi, Tosi, Tosi, Vøllestad, Walsh, White, White   +61 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Evolution of focused streams for viscoelastic flow in spiral microchannels

Microsystems & Nanoengineering, 2023
Particle migration dynamics in viscoelastic fluids in spiral channels have attracted interest in recent years due to potential applications in the 3D focusing and label-free sorting of particles and cells.
Hua Gao, Jian Zhou, Mohammad Moein Naderi, Zhangli Peng, Ian Papautsky   +4 more
doaj   +1 more source