Results 61 to 70 of about 360,193 (299)

Uev1A promotes breast cancer cell migration by up-regulating CT45A expression via the AKT pathway

BMC Cancer, 2021
Background UEV1A encodes a ubiquitin-E2 variant closely associated with tumorigenesis and metastasis, but its underlying mechanism in promoting metastasis remains to be investigated.
Tong Niu, Zhaojia Wu, Wei Xiao
doaj   +1 more source

A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration [PDF]

, 2015
Fascin is an actin-binding and bundling protein that is highly upregulated in most epithelial cancers. Fascin promotes cell migration and adhesion dynamics in vitro and tumour cell metastasis in vivo.
Stramer, Brian M., Parsons, Maddy; id_orcid, Frame, Margaret, Bryan Serrels, Serrels, B, Parsons, M., Asier Jayo, Goult, B. T., Jayo, A., Zanet, J., Villari, G., Villari, G, Fitch, B., Serrels, Bryan, Stramer, BM, Fitch, Briana, Goult, Benjamin T., Frame, M., Jennifer Zanet, Frame, M, Jayo, Asier, Goult, Benjamin T, Goult, BT, Briana Fitch, Brian M. Stramer, Margaret Frame, Fitch, B, Stramer, B. M., Jayo, A, Zanet, Jennifer, Serrels, B., Maddy Parsons, Parsons, M, Giulia Villari, Zanet, J, Benjamin T. Goult, Villari, Giulia   +36 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Run‐of‐river dams as a barrier to the movement of a stream‐dwelling amphibian

Ecosphere, 2020
Human activities frequently create structures that alter the connectivity among habitats or act as barriers to the natural movement of animals. Movement allows individuals to access different habitats, connect life history stages, and maintain genetic ...
Griffin C. Dare, Rylee G. Murray, Danielle M. M. Courcelles, Joshua M. Malt, Wendy J. Palen   +4 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Predation risk in stocking programs: case study on a critically endangered diadromous species, the European sturgeon Acipenser sturio

Frontiers in Marine Science
Juveniles produced in hatcheries for stocking purposes can have compromised behavior compared to wild conspecifics, especially concerning inappropriate anti-predator responses.
Marie-Laure Acolas, Jérémy Tourneur, Thibault Dindart, Frédérique Bau, François Druyer, Bénédicte Lalot, Coralie Roy-Camille, Florent Lalanne, Vanessa Lauronce, Géraldine Loot, Géraldine Loot   +10 more
doaj   +1 more source

Lateral Migration in a Wandering Reach of the Middle Yellow River in Response to Different Boundary Conditions

Applied Sciences, 2020
The Xiaobeiganliu reach is a typical wandering reach of the Middle Yellow River that has rapid and significant channel lateral migration, which may threaten the safety of riparian land and flood control structures.
Jie Li, Yi Zhang, Qingfeng Ji
doaj   +1 more source

Shipping canals on the downstream migration route of European eel (Anguilla anguilla) : opportunity or bottleneck?

, 2021
Migrating fish species are worldwide in decline due to several global changes and threats. Among these causes are man-made structures blocking their freshwater migration routes. Shipping canals with navigation locks play a dual role in this. These canals
Ine Pauwels, Nopens, Ingmar, Raf Baeyens, Mouton, Ans, Jenna Vergeynst, Tom De Mulder, De Mulder, Tom, Vergeynst, Jenna, Ans Mouton, Ingmar Nopens, Pauwels, Ine, Baeyens, Raf   +11 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Evolution of focused streams for viscoelastic flow in spiral microchannels

Microsystems & Nanoengineering, 2023
Particle migration dynamics in viscoelastic fluids in spiral channels have attracted interest in recent years due to potential applications in the 3D focusing and label-free sorting of particles and cells.
Hua Gao, Jian Zhou, Mohammad Moein Naderi, Zhangli Peng, Ian Papautsky   +4 more
doaj   +1 more source