Results 51 to 60 of about 360,193 (299)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

La dévalaison des migrateurs : problèmes et dispositifs

Knowledge and Management of Aquatic Ecosystems, 1999
Cet article, qui actualise le chapitre 13 du n°326-327 du Bulletin Français de la Pêche et de la Pisciculture des mêmes auteurs, fait le bilan des connaissances actuelles sur la migration de dévalaison au niveau des centrales hydroélectriques, que ce ...
LARINIER M., TRAVADE F.
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Thermal conditions in the marine coastal waters as a factor favorable for formation of extra-strong year-classes of Karaginsky pink salmon

Известия ТИНРО
Variability of the timing for downstream migration of juvenile pink salmon from the Hailulya River to the adjacent coastal waters of Karaginsky Bay is considered and influence of the coastal water temperature on strength of the year-classes for two ...
Е. А. Shevlyakov, N. А. Dederer, V. I. Ostrovsky, G. V. Khen   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Efficacité d'un exutoire de dévalaison et d'une barrière acoustique pour les smolts de saumon atlantique (Salmo salar L.) à l'aménagement hydroélectrique de St. Cricq sur le gave d'Ossau.

Knowledge and Management of Aquatic Ecosystems, 1999
Une expérimentation a été conduite en 1996 au niveau de l'aménagement hydroélectrique de St. Cricq (gave d'Ossau) dans le but de tester deux dispositifs de dévalaison destinés à éviter le passage dans les turbines des smolts de saumon atlantique (Salmo ...
TRAVADE F., GOUYOU C., DE FAVERI N.
doaj   +1 more source

Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways

BMC Cancer, 2011
Background Recently it has been shown that radiation induces migration of glioma cells and facilitates a further spread of tumor cells locally and systemically. The aim of this study was to evaluate whether radiotherapy induces migration in head and neck
Schlegel Jürgen, Pigorsch Steffi, Scherer Elias Q, Boulesteix Anne-Laure, Beck Carolin, Piontek Guido, Stark Thomas, Knopf Andreas, Margraf Johanna, Pickhard Anja C, Arnold Wolfgang, Reiter Rudolf   +11 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Downstream Migration and Multiple Dam Passage by Atlantic Salmon Smolts [PDF]

, 2017
The purpose of this study was to investigate behavior and survival of radio-tagged wild and hatchery-reared landlocked Atlantic Salmon Salmo salar smolts as they migrated past three hydropower dams equipped with fish bypass solutions in the Winooski ...
S. D. McCormick, T. Castro-Santos, E. Bergman, D. Nyqvist, Calles, Olle,, W. R. Ardren, Ardren, W. R.,, Bergman, Eva,, L. Greenberg, McCormick, S. D.,, O. Calles, Nyqvist, Daniel,, Greenberg, Larry,, Castro-Santos, Theodore,   +13 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source