Results 81 to 90 of about 360,193 (299)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

T lymphocytes migrate upstream after completing the leukocyte adhesion cascade

Cell Adhesion & Migration, 2019
The leukocyte adhesion cascade is of critical importance for both the maintenance of immune homeostasis and the ability of immune cells to perform effector functions.
Nicholas R. Anderson, Alexander Buffone, Daniel A. Hammer   +2 more
doaj   +1 more source

Effect of grain-sorting waves on alternate bar dynamics: implications of the breakdown of the hydrograph boundary layer [PDF]

Earth Surface Dynamics
Understanding the morphological responses of gravel-bed rivers to changes in external forces (e.g. water and sediment supply conditions) is a critical concern in river science and engineering.
S. Tanabe, T. Iwasaki
doaj   +1 more source

Both doublecortin and doublecortin-like kinase play a role in cortical interneuron migration

, 2007
Type I lissencephaly, a genetic disease characterized by disorganized cortical layers and gyral abnormalities, is associated with severe cognitive impairment and epilepsy.
Rakic, S, Antypa, M, Parnavelas, JG, Walsh, CA, Friocourt, G, Liu, JS   +5 more
core  

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Session E3: Downstream Migration

, 2015
: With the growing numbers of fish migration along the river Rhine and its tributaries, it became clear that not only the upstream, but also the downstream migration must be secured.
Monnier, David
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

French experience in downstream migration devices

, 2006
[Departement_IRSTEA]MA [TR1_IRSTEA]QSA / DYMECOExtrait de documentVarious steps were taken in France during the Nineties to minimize the impact of hydroelectric power installations on fish migration downstream, focusing first on Atlantic salmon and later
Travade, F., Larinier, M.
core   +1 more source

Upstream and downstream migration speed of Prochilodus costatus (Characiformes: Prochilodontidae) in upper São Francisco basin, Brazil

Neotropical Ichthyology
Details of migration dynamics of Neotropical fishes are poorly understood. This study aimed to examine upstream (spawning) and downstream (post-spawning) migration speeds, of curimatá-pioa (Prochilodus costatus) in the São Francisco River basin ...
João de Magalhães Lopes, Carlos Bernardo Mascarenhas Alves, Alexandre Peressin, Paulo Santos Pompeu   +3 more
doaj   +1 more source

Empirical support for sequential imprinting during downstream migration in Atlantic salmon (Salmo salar) smolts. [PDF]

Sci Rep, 2022
Haraldstad T, Forseth T, Olsen EM, Haugen TO, Höglund E.   +4 more
europepmc   +1 more source