Results 91 to 100 of about 397,699 (411)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Attenuation of doxorubicin-induced cardiotoxicity by mdivi-1: a mitochondrial division/mitophagy inhibitor. [PDF]

PLoS ONE, 2013
Doxorubicin is one of the most effective anti-cancer agents. However, its use is associated with adverse cardiac effects, including cardiomyopathy and progressive heart failure.
Mayel Gharanei, Afthab Hussain, Omar Janneh, Helen Maddock   +3 more
doaj   +1 more source

The complexity of mesoporous silica nanomaterials unravelled by single molecule microscopy [PDF]

, 2011
Mesoporous silica nanomaterials are a novel class of materials that offer a highly complex porous network with nanometre-sized channels into which a wide amount of differently sized guests can be incorporated.
Aguado, Alberius, Angloher, Angloher, Beck, Benes, Besson, Betzig, Billinge, Binnig, Binnig, Binning, Brinker, Cagnol, Cauda, Cauda, Cauda, Christoph Bräuchle, Collins, Cott, D'Arpa, De Vos, Dickson, Feil, Fowler, Giri, Giri, Gustafsson, Han, Heintzmann, Hell, Hell, Hellriegel, Hellriegel, Hess, Holtrup, Jens Michaelis, Jung, Jung, Jung, Katiyar, Kirstein, Kresge, Kukla, Lai, Lebold, Lebold, Maschmeyer, Moerner, Moerner, Moerner, Moerner, Munoz, Nolde, O'Shaughnessy, Orrit, Oye, Petkov, Platschek, Provendier, Rebbin, Roy, Rust, Sakamoto, Sauer, Schlossbauer, Schuth, Scott, Shen, Timo Lebold, Torchilin, Torney, Vallet-Regi, Visintin, Wagner, Yamamoto, Yamamoto, Yang, Ye, Ying, Yokoi, Zhao, Zhao, Zürner   +83 more
core   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Deprenyl, an old drug with new anticancer potential: Mini review [PDF]

arXiv, 2021
The anticancer potential of monoamine oxidase (MAO) was observed in pre-clinical assays conducted with cell cultures and animals. L-Deprenyl (DEP) causes apoptosis in melanoma, leukemia and mammary cells. High-dose DEP has shown toxicity in mammary and pituitary cancers, as well as in monoblastic leukemia, in rats.
arxiv  

Doxorubicin-mediated radiosensitivity in multicellular spheroids from a lung cancer cell line is enhanced by composite micelle encapsulation

International Journal of Nanomedicine, 2012
Wen-Hong Xu,1 Min Han,2 Qi Dong,3 Zhi-Xuan Fu,3 Yuan-Yuan Diao,2 Hai Liu,3 Jing Xu,3 Hong-Liang Jiang,4 Su-Zhan Zhang,3 Shu Zheng,3 Jian-Qing Gao,2 Qi-Chun Wei11Department of Radiation Oncology, The Second Affiliated Hospital, School of Medicine ...
Xu WH, Han M, Dong Q, Fu ZX, Diao YY, Liu H, Xu J, Jiang HL, Zhang SZ, Zheng S, Gao JQ, Wei QC   +11 more
doaj  

Topoisomerase II inhibitors induce DNA damage-dependent interferon responses circumventing Ebola virus immune evasion [PDF]

, 2017
Ebola virus (EBOV) protein VP35 inhibits production of interferon alpha/beta (IFN) by blocking RIG-I-like receptor signaling pathways, thereby promoting virus replication and pathogenesis.
Adolfo García-Sastre, Alexander Bukreyev, Ana Fernandez-Sesma, Benjamin C. Yen, Bersabeh Tigabu, Christopher F. Basler, Colette A. Pietzsch, Daisy W. Leung, Lorraine K. Morlock, Maria T. Sanchez-Aparicio, Noelle S. Williams, Priya Luthra, Sebastian Aguirre, Terence S. Dermody   +13 more
core   +3 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Integrative Wireless Device for Remote Continuous Blood Biomarker Monitoring [PDF]

arXiv, 2021
To perform precision medicine in realtime at home, a device capable of long distance continuously monitoring target biomolecules in unprocessed blood under dynamic situations is essential. In this study, an integrative buffer free wireless device is developed to measure drug concentrations in patients blood in real time for remote clinical healthcare ...
arxiv  

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source