Results 91 to 100 of about 241,371 (303)

Doxorubicin-induced cardiomyocyte toxicity- protective effects of endothelial cells in a tri-culture model system

, 2018
Doxorubicin-induced cardiomyopathy is a clinically prevalent pathology, occurring as a sequelae following chemotherapy for cancer patients. In particular, the ‘first dose’ effect has been particularly challenging, given the heterogeneous and ...
A Hidalgo-Bastida (24003843), May Azzawi (23878188), D Sharp (13487539), E Alias (24003837), V Parikh (24003840), M Wilkinson (7746431), R Shakur (24003849), T Gibson (13510249), K Davidge (24003846)   +8 more
core  

Doxorubicin-Loaded Photosensitizer-Core pH-Responsive Copolymer Nanocarriers for Combining Photodynamic Therapy and Chemotherapy

, 2017
Photodynamic therapy (PDT) is an emerging method for the treatment of cancer. Combination of PDT and chemotherapy is a hot topic though the two therapies could not simultaneously exert their perfect effect in vivo.
Xiaodong Sun (166163), Yiguang Jin (841832), Xiaohan Zhang (2291644), Baolei Zhang (3965114), Hongxiang Kang (3965111), Fuli Zhang (506665), Qiu Li (2127361)   +6 more
core   +1 more source

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer

Advanced Science, EarlyView.
Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li, Anguo Zhao, Qi Zhuang, Lei Peng, Rui Liang, Jiadong Zhao, Yang Liu, Dashi Deng, Peng Yu, Xiqi Peng, Shaohua Zhang, Song Wu   +11 more
wiley   +1 more source

Supplementary Figure S2 from Mitochondria-Targeted Doxorubicin: A New Therapeutic Strategy against Doxorubicin-Resistant Osteosarcoma

, 2016
Expression of Pgp and MRP1 in doxorubicin-sensitive and doxorubicin-resistant osteosarcoma ...
Chiara Riganti (401982), Costanzo Costamagna (2194669), Shana O. Kelley (401147), Marilù Fanelli (3369038), Joanna Kopecka (401984), Massimo Serra (123292), Elena Gazzano (806376), Eleonora Mungo (5623370), Sae Rin Jean (1528060), Ilaria Buondonno (2211751), Valentina Audrito (12227342), Silvia Deaglio (7499969), Claudia M. Hattinger (15072325), Iris C. Salaroglio (6190355), Ilaria Roato (23147)   +14 more
core   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

NADPH oxidase 2 mediates cardiac sympathetic denervation and myocyte autophagy, resulting in cardiac atrophy and dysfunction in doxorubicin-induced cardiomyopathy

Scientific Reports
Doxorubicin has been used extensively as a potent anticancer agent, but its clinical use is limited by its cardiotoxicity. However, the underlying mechanisms remain to be fully elucidated.
Yuan Ma, Hui-Ping Zhao, Li-Guo Yang, Lu Li, Ai-Lin Wang, Xiao-Juan Zhang, Ke Wang, Bin Yang, Zong-Feng Zhu, Pei-Jun Zhang, Jia-Pu Wang, Rui-Fang Chi, Bao Li, Fu-Zhong Qin, Zhi-Peng Wang   +14 more
doaj   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Pegylated liposomal doxorubicin in ovarian cancer

, 2009
Robert Strother1,2, Daniela Matei1–51Department of Medicine, 2Indiana University Melvin and Bren Simon Cancer Center, 3Department of Obstetrics and Gynecology, 4Department of Biochemistry and Molecular Biology, 5VA Roudebush Hospital Indiana ...
Robert Strother, Daniela Matei
core  

Immunoproteasome Inhibitor–Doxorubicin Conjugates Target Multiple Myeloma Cells and Release Doxorubicin upon Low-Dose Photon Irradiation

, 2020
Proteasome inhibitors are established therapeutic agents for the treatment of hematological cancers, as are anthra­cyclines such as doxorubicin. We here present a new drug targeting approach that combines both drug classes into a single molecule ...
Dennis P. A. Wander (4006301), Sabina Y. van der Zanden (8706243), Patrick M. Dekker (8706240), Jacques J. C. Neefjes (8706246), Herman S. Overkleeft (128584), Santina Maiorana, Santina Maiorana (5389058), Sander I. van Kasteren (8706249), Sabina Y. van der Zanden, Elmer Maurits, Elmer Maurits (5210636), Dennis P. A. Wander, Jacques J. C. Neefjes, Patrick M. Dekker, Bogdan I. Florea, Sander I. van Kasteren, Herman S. Overkleeft, Michel J. van de Graaff (3205560), Bogdan I. Florea (1330800), Michel J. van de Graaff   +19 more
core   +1 more source