Results 111 to 120 of about 413,339 (385)

H2O2‐Generating Advanced Nanomaterials for Cancer Treatment

Advanced Functional Materials, EarlyView.
H2O2‐generating nanoplatforms can exploit tumor redox imbalance for O2 and toxic reactive oxygen species generation, leading to hypoxia reversal, and apoptosis of cancer cells, respectively. This review highlights the mechanisms of these nanoplatforms, including exogenous H₂O₂ delivery, endogenous amplification, and metal peroxides, which leads to ...
Kiyan Musaie, Samin Abbaszadeh, Kik Marais, Vahideh Nosrati‐Siahmazgi, Saman Rezaei, Bo Xiao, Kamal Dua, Hélder A. Santos, Mohammad‐Ali Shahbazi   +8 more
wiley   +1 more source

The complexity of mesoporous silica nanomaterials unravelled by single molecule microscopy [PDF]

, 2011
Mesoporous silica nanomaterials are a novel class of materials that offer a highly complex porous network with nanometre-sized channels into which a wide amount of differently sized guests can be incorporated.
Aguado, Alberius, Angloher, Angloher, Beck, Benes, Besson, Betzig, Billinge, Binnig, Binnig, Binning, Brinker, Cagnol, Cauda, Cauda, Cauda, Christoph Bräuchle, Collins, Cott, D'Arpa, De Vos, Dickson, Feil, Fowler, Giri, Giri, Gustafsson, Han, Heintzmann, Hell, Hell, Hellriegel, Hellriegel, Hess, Holtrup, Jens Michaelis, Jung, Jung, Jung, Katiyar, Kirstein, Kresge, Kukla, Lai, Lebold, Lebold, Maschmeyer, Moerner, Moerner, Moerner, Moerner, Munoz, Nolde, O'Shaughnessy, Orrit, Oye, Petkov, Platschek, Provendier, Rebbin, Roy, Rust, Sakamoto, Sauer, Schlossbauer, Schuth, Scott, Shen, Timo Lebold, Torchilin, Torney, Vallet-Regi, Visintin, Wagner, Yamamoto, Yamamoto, Yang, Ye, Ying, Yokoi, Zhao, Zhao, Zürner   +83 more
core   +1 more source

MMP inhibitors attenuate doxorubicin cardiotoxicity by preventing intracellular and extracellular matrix remodeling.

Cardiovascular Research, 2020
AIMS Heart failure is a major complication in cancer treatment due to the cardiotoxic effects of anticancer drugs, especially from the anthracyclines such as doxorubicin.
Brandon Y H Chan, A. Roczkowsky, W. Cho, Mathieu Poirier, C. Sergi, Vic Keschrumrus, Jared M. Churko, H. Granzier, R. Schulz   +8 more
semanticscholar   +1 more source

Hollow‐Structured Nanorobot with Excellent Magnetic Propulsion for Catalytic Pollutant Degradation, Anti‐Bacterial and Biofilm Removal

Advanced Healthcare Materials, EarlyView.
A hollow‐structured Fe3O4@AgAu@PDA‐ZnPc nanosphere has been developed, exhibiting controllable catalytic activity and “photothermal‐photodynamic‐Ag+” coupling antibacterial characteristics. When subjected to a rotating magnetic field, these performances are uniquely enhanced by magnetic propulsion, allowing the nanosphere to function as a magnetic ...
Jing Wang, Guangjin Yu, Qunling Fang, Yunqi Xu, Jie Zhang, Ailing Hui, Shouhu Xuan, Ken Cham‐Fai Leung   +7 more
wiley   +1 more source

Not only P-glycoprotein: amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins [PDF]

, 2017
The development of drug resistance continues to be a dominant hindrance toward curative cancer treatment. Overexpression of a wide-spectrum of ATP-dependent efflux pumps, and in particular of ABCB1 (P-glycoprotein or MDR1) is a well-known resistance ...
Assaraf, Yehuda G., Colotti, Gianni, Fazi, Francesco, Genovese, Ilaria, Ilari, Andrea   +4 more
core   +1 more source

A comparison between liposomal and nonliposomal formulations of doxorubicin in the treatment of cancer: An updated review

Archives of Pharmacy Practice, 2016
Cancer remains a major cause of hospitalization and death every year. From time to time, new formulations of anticancer drugs are available in the market and draw the concern of healthcare professionals in terms of the superiority, toxicology, and cost ...
Yik Hoe Ngan, Manish Gupta
doaj   +1 more source

Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers

Advanced Healthcare Materials, EarlyView.
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto, Moisés L. Pinto, Christian Serre   +2 more
wiley   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

α-Hexylcinnamaldehyde synergistically increases doxorubicin cytotoxicity towards human cancer cell lines [PDF]

, 2016
α-Hexylcinnamaldehyde (HCA), a compound derived from cinnamaldehyde, was evaluated for its potential chemosensitizing ...
DI GIACOMO, Silvia, DI SOTTO, Antonella, El Readi, Mahmoud Zaki, Mazzanti, Gabriela, Wink, Michael   +4 more
core  

The combination of temozolomide-irinotecan regresses a doxorubicin-resistant patient-derived orthotopic xenograft (PDOX) nude-mouse model of recurrent Ewing's sarcoma with a FUS-ERG fusion and CDKN2A deletion: Direction for third-line patient therapy. [PDF]

, 2017
The aim of the present study was to determine the usefulness of a patient-derived orthotopic xenograft (PDOX) nude-mouse model of a doxorubicin-resistant metastatic Ewing's sarcoma, with a unique combination of a FUS-ERG fusion and CDKN2A deletion, to ...
Bouvet, Michael, Chishima, Takashi, Dry, Sarah M, Eckardt, Mark A, Eilber, Fritz C, Elliott, Irmina A, Endo, Itaru, Hiroshima, Yukihiko, Hoffman, Robert M, Igarashi, Kentaro, Kawaguchi, Kei, Kiyuna, Tasuku, Li, Yunfeng, Matsuyama, Ryusei, Miyake, Kentaro, Miyake, Masuyo, Momiyama, Masashi, Murakami, Takashi, Nelson, Scott D, Russell, Tara A, Singh, Arun S   +20 more
core   +1 more source