Results 121 to 130 of about 397,699 (411)
Cardiovascular Therapeutics, 2023 Background. Doxorubicin-induced cardiotoxicity has been closely concerned in clinical practice. Rev-erbα is a transcriptional repressor that emerges as a drug target for heart diseases recently. This study is aimed at investigating the role and mechanism
Runmei Zou +4 more
doaj +1 more source
Advanced Functional Materials, EarlyView.The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang +9 more
wiley +1 more source
Biocompatible carbon nitride-based light-driven microswimmer propulsion in biological and ionic media with responsive on-demand drug delivery [PDF]
arXiv, 2021 We propose two-dimensional organic poly(heptazine imide) (PHI) carbon nitride microparticles as light-driven microswimmers in various ionic and biological media. Their demonstrated high-speed (15-23 $\mu$m/s) swimming in multi-component ionic solutions with concentrations up to 1 M and without dedicated fuels is unprecedented, overcoming one of the ...
arxiv
Doxorubicin pharmacokinetics in lymphoma patients treated with doxorubicin-loaded eythrocytes
Haematologica, 2007 Doxorubicin-loaded erythrocytes (DLE) were administrated to 15 lymphoma patients. Antibiotic peak concentration in blood decreased by 55%, doxorubicin circulated several times longer, and the area under the concentration-time curve increased 5 times if compared with standard doxorubicin administration. The DLE was well tolerated by patients.
Skorokhod, Oleksii +7 more
openaire +6 more sources
The role of the microvascular network structure on diffusion and consumption of anticancer drugs [PDF]
, 2017 We investigate the impact of microvascular geometry on the transport of drugs in solid tumors, focusing on the diffusion and consumption phenomena. We embrace recent advances in the asymptotic homogenization literature starting from a double Darcy—double
Mascheroni, Pietro, Penta, Raimondo
core +1 more source
Advanced Functional Materials, EarlyView.Designer DNA Architecture‐templated Drug Conjugates (DDA‐DCs) are comprised of a DNA nanomaterial decorated with multiple drug‐loaded DNA aptamers. DDA‐DCs use a combination of multiple aptamer types, each recognizing a different membrane protein to achieve precise targeting of cancer cells.
Abhisek Dwivedy +19 more
wiley +1 more source
Genomics-guided molecular maps of coronavirus targets in human cells: a path toward the repurposing of existing drugs to mitigate the pandemic [PDF]
arXiv, 2020 Human genes required for SARS-CoV-2 entry into human cells, ACE2 and FURIN, were employed as baits to build genomics-guided maps of up-stream regulatory elements, their expression and functions in human body, including pathophysiologically-relevant cell types.
arxiv
Doxorubicin Induces Lamellipodia Formation and Cell Migration
ISCC (Indonesian Journal of Cancer Chemoprevention), 2017 Breast cancer is the main cause of cancer death among women, especially breast cancer metastasis. Metastasis process begins with the ability of cell cancer invasion.
Nur Dina Amalina +2 more
doaj +1 more source
CD24 Expression and differential resistance to chemotherapy in triple-negative breast cancer. [PDF]
, 2017 Breast cancer (BC) is a leading cause of cancer-related death in women. Adjuvant systemic chemotherapies are effective in reducing risks of recurrence and have contributed to reduced BC mortality.
Apple, Sophia +9 more
core +1 more source
Cardiovascular Research, 2020 AIMS Heart failure is a major complication in cancer treatment due to the cardiotoxic effects of anticancer drugs, especially from the anthracyclines such as doxorubicin.
Brandon Y H Chan +8 more
semanticscholar +1 more source