Results 191 to 200 of about 63,987 (250)
Advances in Immunological Combination Therapy for Colorectal Cancer
iMetaMed, EarlyView.Review the progress of combined immunotherapy for colorectal cancer. ABSTRACT Immune checkpoint inhibitors (ICIs) have been utilized extensively and shown to be therapeutically beneficial in the treatment of solid tumors in recent years. Nonetheless, considerable heterogeneity in Colorectal cancer (CRC) requires careful consideration.
Jiayue Wu +7 more
wiley +1 more source
iMeta, EarlyView.The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source
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Journal of Drug Targeting, 1996
Doxorubicin is a potent antineoplastic agent with activity against numerous human cancers. Encapsulation of doxorubicin inside a liposome alters bioavailability, biodistribution and thus its biological activity significantly. The physical properties of the liposome (size, lipid components and lipid dose) play a major role in determining drug retention ...
Pieter Cullis
exaly +3 more sources
Doxorubicin is a potent antineoplastic agent with activity against numerous human cancers. Encapsulation of doxorubicin inside a liposome alters bioavailability, biodistribution and thus its biological activity significantly. The physical properties of the liposome (size, lipid components and lipid dose) play a major role in determining drug retention ...
Pieter Cullis
exaly +3 more sources
THE HEPATIC PHARMACOKINETICS OF DOXORUBICIN AND LIPOSOMAL DOXORUBICIN
Drug Metabolism and Disposition, 2004To determine the role of the hepatic sinusoidal endothelium in the hepatic disposition of liposomal doxorubicin, we compared the hepatic pharmacokinetics of doxorubicin hydrochloride and the pegylated, liposomal formulation of doxorubicin (Caelyx). The multiple indicator-dilution technique and electron microscopy were used to study the disposition of ...
Sarah N, Hilmer +3 more
openaire +2 more sources
Journal of Nanoscience and Nanotechnology, 2014
Doxorubicin is one of the most widely administered drugs for treatment of cancer. The shortcomings commonly encountered with this drug are severe cardiotoxicity, narrow therapeutic indices, and the development of multiple drug resistance. Hence, several nanoparticulate drug delivery systems have been designed to overcome these limitations and to ...
Kannan, Deepa +2 more
openaire +2 more sources
Doxorubicin is one of the most widely administered drugs for treatment of cancer. The shortcomings commonly encountered with this drug are severe cardiotoxicity, narrow therapeutic indices, and the development of multiple drug resistance. Hence, several nanoparticulate drug delivery systems have been designed to overcome these limitations and to ...
Kannan, Deepa +2 more
openaire +2 more sources
Doxorubicin-heparin complex: reduction of cardiotoxicity of doxorubicin
Journal of Cancer Research and Clinical Oncology, 1995We have compared the antitumor activity and cardiotoxicity of free doxorubicin (Dox) and doxorubicin-heparin complex in vivo and in vitro. Dox and Dox-heparin complex equally inhibited the DNA synthesis of leukemic cells and showed a similar anticancer activity against tumor-bearing mice.
Y, Mizuno +5 more
openaire +2 more sources
Pharmacokinetics and metabolism of iodo-doxorubicin and doxorubicin in humans
European Journal of Clinical Pharmacology, 1990The pharmacokinetics of doxorubicin (DOX), iodo-doxorubicin (I-DOX) and their metabolites in plasma has been examined in five patients each receiving 50 mg/m2 of both anthracyclines as a bolus injection. Terminal half-life, mean residence time (MRT), peak plasma concentration Cmax, and area under the curve (AUC) appeared smaller for I-DOX, whereas its ...
K, Mross +4 more
openaire +2 more sources
Annals of Internal Medicine, 1980
Excerpt To the editor: In a recent letter Cosgriff(1) reported onset of ventricular dysrhythmia in a 21-year-old man after administration of doxorubicin and noted the association of doxorubicin, dy...
openaire +2 more sources
Excerpt To the editor: In a recent letter Cosgriff(1) reported onset of ventricular dysrhythmia in a 21-year-old man after administration of doxorubicin and noted the association of doxorubicin, dy...
openaire +2 more sources