Results 191 to 200 of about 241,371 (303)

Autonomous Nanomedicine: Closing the Biological Validation Gap

Exploration, EarlyView.
Delivery of nanoparticles to tumors has not improved in over fifteen years, and biological testing remains slow and separate from formulation design. This review proposes adding a Biology step to the design cycle, using organ chips and patient‐derived organoids, and assesses the readiness of each required technology.
Yan Jun Lin, Izabella Komperda
wiley   +1 more source

Neoadjuvant concurrent or sequential anthracycline-containing chemotherapy and HER2-targeted agents for HER2-positive breast cancer: a randomized phase 2 study (METIS). [PDF]

Signal Transduct Target Ther
Zheng Q, Wang S, Wu Z, Zhong M, Xu F, Ma S, Zhang Y, Zhang L, Shi Y, Wang Y, Huang H, Ma X, Xu X, Li H, Li J, Bi X, Huang J, Jiang K, An X, Hong R, Chen M, Xue C, Zhong Y, Yuan Z, Xia W.   +24 more
europepmc   +1 more source

“Nature's Polymer Reimagined: Conventional and Green Routes to Pectin, Its Bioactive Promise and Industrial Applications”

Food Chemistry International, EarlyView.
Pectin, a versatile natural polymer, is extracted through conventional and emerging green extraction methods, offering multifunctional bioactive properties useful in food, pharmaceutical, and environmental applications. ABSTRACT Pectin, a molecular tapestry woven from diverse polysaccharides, holds a pivotal role across food, pharmaceutical, and ...
Afra Anika Rafique, Aunwesha Sahani, Md Morsaline Billah, Kazi Mohammed Didarul Islam   +3 more
wiley   +1 more source

Binding of Anthracyclines Within DNA-Topoisomerase ΙΙ Cleavage Complexes: Thermodynamics and Interactions. [PDF]

J Chem Inf Model
Mikaelian G, Sarimveis H, Theodorou DN, Megariotis G.   +3 more
europepmc   +1 more source

Implantable electrochemical sensors for continuous blood monitoring

FlexMat, EarlyView.
Implantable electrochemical sensors enable direct, in situ, and continuous blood monitoring, shifting diagnosis from population‐based averages to dynamic, individualized analysis. This review systematically examines the influence of the unique blood properties on sensor design.
Kuangyi Zou, Yuanzhen Wang, Haidong Wang, Ye Zhang   +3 more
wiley   +1 more source

Extracellular vesicles derived from edible plants and edible fungi: Compositional characteristics, engineering strategies and biofunctions

Food Biomacromolecules, EarlyView.
Non‐animal extracellular vesicles as bioactive‐compound carriers: compositional characteristics, engineering strategies, and biofunctions. Abstract Animal‐derived extracellular vesicles (EVs) were widely used for bioactive compound delivery but constrained by complex origins, potential immunogenicity, and pathogen contamination.
Jiahao Yu, Rongheng Chen, Yuxuan Liu, Yizhen Xie, Fangyu Fan, Simin Feng, Ping Shao   +6 more
wiley   +1 more source

The p53-Associated Regulation of ATF4 mRNA Expression Involves p21 and p130 in a Stress-Dependent Manner. [PDF]

Cells
Dalina A, Shilyaeva M, Kovaleva I, Chumakov P.   +3 more
europepmc   +1 more source

Treatment Outcomes in Osteosarcoma of the Head and Neck: A Systematic Review and Meta‐Analysis

Head &Neck, EarlyView.
ABSTRACT Background Head and neck osteosarcomas (HNOS) are rare, accounting for ~1% of head and neck malignancies. This study systematically evaluated the role of chemotherapy (CT) and radiotherapy (RT) on survival outcomes. Methods A systematic review and meta‐analysis were performed following PRISMA guidelines across six databases.
Angela Magri, Andrea Quaiattini, Alex Mlynarek, Keith Richardson, Michael Hier, Nader Sadeghi, Ramy Saleh, Ahmed Aoude, Khalil Sultanem, Salvatore Di Maio, Tamara Mijovic, Marco Mascarella, Emily Kay‐Rivest   +12 more
wiley   +1 more source

CMTM6/PD-L1-targeted AAV promotes anti-tumor immune responses and chemotherapy responsiveness. [PDF]

Front Immunol
Chen R, Pang X, Li F, Wu S, Wang Y, Zheng X, Zhao Y, Qiu F, Chen L, Du F, Chen C, Zhang R, Li Z, Long Y, Gong L, Feng M.   +15 more
europepmc   +1 more source

Cutaneous Leiomyosarcoma of the Head and Neck: Appreciation of a More Indolent Biological Behavior and Implications for Its Management

Head &Neck, EarlyView.
ABSTRACT Background Leiomysosarcoma (LMS) is generally associated with high metastatic potential and poor survival. Cutaneous LMS (cLMS) has been considered a different entity with more indolent biological behavior. Methods A narrative review was performed to assess the biological behavior of cLMS, with special attention for the head and neck location.
Eelco de Bree, Remco de Bree, Carlos Chiesa‐Estomba, Orlando Guntinas‐Lichius, M. P. Sreeram, Dimosthenis Michelakis, Karthik N. Rao, Alessandra Rinaldo, Alfio Ferlito   +8 more
wiley   +1 more source