Results 211 to 220 of about 241,371 (303)

Cytotoxic and Pro‐Apoptotic Effects of the Compound 2‐Carboxy‐2‐Heptano‐Indolin‐3‐One in HeLa Cell Spheroids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Indolinones are compounds with recognized antineoplastic properties and can act as inhibitors of multiple kinases. However, the antitumor effects of 2‐carboxy‐2‐heptano‐indolin‐3‐one (IDC) have not yet been investigated in cervical cancer models.
Agda Lorena Corrêa Rocha, Caroline Fernandes Westin, Erika Tyemi Goya Niekawa, Galdino Andrade, Luan Vitor Alves de Lima, Lucas Karpinski Risson, Matheus Felipe da Silva, Stefani Fabiola Alarcon, Mário Sérgio Mantovani   +8 more
wiley   +1 more source

Phosphatidylserine-based liposomes encapsulating DMX-5804 protect against doxorubicin-induced cardiotoxicity.

RSC Pharm
Tetterton-Kellner J, Miserendino A, Tariq I, Jensen BC, Nguyen J.   +4 more
europepmc   +1 more source

Anthracycline cardiotoxicity: role of metabolic vulnerability induced by cardiac pressure overload. [PDF]

Eur Heart J
Galán-Arriola C, Pérez-Camargo D, Jorge I, Bautista V, Ayaon-Albarrán A, Pérez-Martínez C, de Molina-Iracheta A, Cádiz L, Medina-Hernández D, Caballero-Henares C, Lopez-Martín GJ, Vázquez J, Ochala J, Fuster V, Sánchez-González J, Ibáñez B.   +15 more
europepmc   +1 more source

Shikonin Promotes Apoptosis in Multiple Myeloma Cells Through the PKM2‐AMPK‐PGC1α Metabolic Axis

Journal of Clinical Laboratory Analysis, EarlyView.
High PKM2 expression in MM is associated with a poor prognosis. Shikonin represents a promising PKM2‐targeted agent for MM therapy, offering a unique metabolic intervention strategy to improve drug resistance, bone disease, and the immune microenvironment. ABSTRACT Background Multiple myeloma (MM) is an incurable plasma malignancy.
Fengping Peng, Yu Gao, Ziqi Zhang, Ling Deng, Honglei Liu, Xiaowei Liang, Chunyan Liu, Rong Fu   +7 more
wiley   +1 more source

Design of a yeast-based bio-interface on an optical fiber SPR platform toward drug adsorption monitoring. [PDF]

Beilstein J Nanotechnol
Kitaya N, Yamanaka D, Morita K, Naito R, Suhara H, Suzuki K, Nakajima H, Moriiwa Y, Morioka K, Yanagida A, Shoji A.   +10 more
europepmc   +1 more source

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, EarlyView.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

Integrated hs-cTnI, global longitudinal strain, and coronary artery calcium for risk stratification of anthracycline-related cardiac dysfunction in multiple myeloma. [PDF]

Front Cardiovasc Med
Zhang X, Yu Z.
europepmc   +1 more source

Gymnema sylvestre: Bioactive constituents, health benefits, and emerging applications in nutraceuticals and functional foods

JSFA reports, EarlyView.
Abstract Gymnema sylvestre (Retz.) R.Br. ex‐Schult., commonly known as “gurmar” or “sugar destroyer,” belongs to the Apocynaceae family and is traditionally used in Ayurveda for diabetes management. This review synthesizes ethnomedicinal evidence with contemporary pharmacological studies, to evaluate the therapeutic properties and mechanistic actions ...
Faiza Saeed, Muhammad Tauseef Sultan, Hassan Raza, Ahmad Mujtaba Noman, Nimra Haroon, Entessar Mohammad Al Jbawi   +5 more
wiley   +1 more source

Neutrophil extracellular traps induce chemoresistance in human breast cancer cells through the PI3K/AKT/NF-κB pathway. [PDF]

Front Immunol
Souza JL, Almeida VH, Martins-Cardoso K, Carneiro LDT, Azevedo VRD, Nestal de Moraes G, Monteiro RQ.   +6 more
europepmc   +1 more source

Ewing's Sarcoma in Adults: A Predictive Nomogram and Survival Analysis of a Cohort of 937 Patients

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background Ewing sarcoma is a rare malignancy of bone and soft tissue that most commonly affects children, adolescents, and young adults. Although multimodal treatment has improved survival in localised disease, outcomes remain poorer in adults, particularly in those with metastatic disease, larger tumours, or anatomically complex primary ...
Jonathan Gibson, Ben Thompson, Katie Williams, Chuck Lam, Shashank Chapala, Morgan Jones, Rajesh Botchu   +6 more
wiley   +1 more source