Overexpression of the protein kinase CK2 increases the survival and resistance to chemotherapy of acute myeloid leukemia cells [PDF]
, 2013 Background: The critical role of protein kinase CK2 in the regulation of cellular apoptosis suggests its may be involvement in tumor cell resistance to both conventional and unconventional therapies.
PAVAN, LAURA
core +1 more source
Advanced Science, EarlyView.Enhanced arginine uptake is a critical feature of metabolic reprogramming in PTCL, characterized by elevated expression of the arginine transporter SLC3A2. SLC3A2‐mediated arginine uptake facilitates PTCL proliferation and survival by enhancing OXPHOS metabolism and inducing immune evasion.
Yimin Ren +13 more
wiley +1 more source
Learning Chemotherapy Drug Action via Universal Physics-Informed Neural Networks [PDF]
arXivQuantitative systems pharmacology (QSP) is widely used to assess drug effects and toxicity before the drug goes to clinical trial. However, significant manual distillation of the literature is needed in order to construct a QSP model. Parameters may need to be fit, and simplifying assumptions of the model need to be made.
arxiv
Notch signaling pathway mediates Doxorubicin-driven apoptosis in cancers
Cancer Management and Research, 2018 Zixin Huang,1,* Shuibin Lin,2,* Chongde Long,1 Xin Zhou,1 Yuting Fan,1 Xielan Kuang,1,3 Jia He,1 Jie Ning,1 Han Zhang,1 Qingjiong Zhang,1 Huangxuan Shen1,3 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University ...
Huang Z +10 more
doaj
A prospective randomized trial of adjuvant chemotherapy with bolus versus continuous infusion of doxorubicin in patients with high-grade extremity soft tissue sarcoma and an analysis of prognostic factors [PDF]
, 1991 Ephraim S. Casper +6 more
openalex +1 more source
Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species
Advanced Science, EarlyView.This study identifies ferroptosis as a key driver of cellular senescence, with its inhibition delaying aging and extending healthspan across species. During senescence, ferroptosis worsens, increasing oxidative stress and lipid peroxidation, which accelerate aging.
Hai‐Jun Fu +15 more
wiley +1 more source
Doxorubicin cardiomyopathy is associated with a decrease in calcium release channel of the sarcoplasmic reticulum in a chronic rabbit model. [PDF]
, 1993 Debra A. Dodd +6 more
openalex +1 more source
Advanced Science, EarlyView.This work summarizes the efficacy and mechanisms of probiotics in CRC treatment, providing a comprehensive overview of various encapsulation methods such as microcapsules, hydrogels, single‐cell nanocoatings, and nanofibers for targeted probiotic delivery to inflammatory sites, with particular emphasis on the potential advantages of emerging single ...
Hao Zhong +5 more
wiley +1 more source
Phase III trial of cyclophosphamide versus cyclophosphamide, doxorubicin, and methotrexate in hormone-refractory prostatic cancer: A hoosier oncology group study [PDF]
, 1992 Scott Saxman +6 more
openalex +1 more source
Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems
The Journal of pharmacy and pharmacology, 2013 Oktay Tacar, P. Sriamornsak, C. Dass
semanticscholar +1 more source