Results 231 to 240 of about 397,699 (411)

The diagnosis, classification, and treatment of sarcoma in this era of artificial intelligence and immunotherapy

Cancer Communications, Volume 42, Issue 12, Page 1288-1313, December 2022., 2022
Abstract Soft‐tissue sarcomas (STS) represent a group of rare and heterogeneous tumors associated with several challenges, including incorrect or late diagnosis, the lack of clinical expertise, and limited therapeutic options. Digital pathology and radiomics represent transformative technologies that appear promising for improving the accuracy of ...
Amandine Crombé, Mathtieu Roulleau‐Dugage, Antoine Italiano   +2 more
wiley   +1 more source

Effect of ICRF-187 on doxorubicin-induced myocardial effects in the mouse and guinea pig

, 1982
William E. Perkins, Regine Schroeder, Richard A. Carrano, A. R. Imondi   +3 more
openalex   +2 more sources

Infusional cyclophosphamide, doxorubicin, and etoposide in human immunodeficiency virus- and human T-cell leukemia virus type I-related non-Hodgkin's lymphoma: a highly active regimen [PDF]

, 1993
J. A. Sparano, Wiernik Ph, Margery Strack, Andrea Leaf, Norwin H. Becker, ES Valentine   +5 more
openalex   +1 more source

Elasticity‐Driven Nanomechanical Interaction to Improve the Targeting Ability of Lipid Nanoparticles in the Malignant Tumor Microenvironment

Advanced Science, EarlyView.
The elasticity of lipid nanoparticles (LNPs) is essential to their tumor‐targeting efficacy. Softer LNPs penetrate tumors faster and more easily enter into softer cancer cells, while stiffer LNPs show prolonged retention in stiffer tumors. The presence of protumoral M2 macrophages enhances the LNPs uptake into stiffer cancer cells, facilitating ...
Eunhee Lee, Loi Nguyen Dang, Jinsol Choi, Haesoo Kim, Lyndon Bastatas, Soyeun Park   +5 more
wiley   +1 more source

Synthesis and antitumor activity of 3'-deamino-3'-hydroxydoxorubicin. A facile procedure for the preparation of doxorubicin analogs.

, 1984
Derek Horton, Waldemar Priebe, Oscar Varela   +2 more
openalex   +2 more sources

Isolated single lung perfusion with doxorubicin is effective in eradicating soft tissue sarcoma lung metastases in a rat model [PDF]

, 1994
Benny Weksler, Jeffrey T. Lenert, Bruce Ng, Michael Burt   +3 more
openalex   +1 more source

Human induced pluripotent stem cell–derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity

Nature Network Boston, 2016
P. Burridge, Y. F. Li, Elena Matsa, Haodi Wu, S. Ong, Arun Sharma, Alexandra Holmström, Alex C. Y. Chang, Michael Coronado, Antje D. Ebert, J. Knowles, M. Telli, R. Witteles, H. Blau, D. Bernstein, R. Altman, Joseph C. Wu   +16 more
semanticscholar   +1 more source

Cardiac Slc25a49‐Mediated Energy Reprogramming Governs Doxorubicin‐Induced Cardiomyopathy through the G6P–AP‐1–Sln Axis

Advanced Science, EarlyView.
Doxorubicin‐induced cardiomyopathy involves mitochondrial energy metabolism dysfunction, exacerbated by cardiomyocyte‐specific Slc25a49 deficiency via oxidative phosphorylation (OXPHOS) suppression and glycolysis activation. The Slc25a49–glucose‐6‐phosphate (G6P)–activator protein‐1 (AP‐1) axis drives myocardial injury by upregulating Sln, disrupting ...
Sitong Wan, Jingyi Qi, Yi Xia, Chang Fan, Teng Xu, Xu Zhang, Jiaxin Shi, Chenxuan Wang, Yitong Cheng, Dongyuan Zhang, Rong Liu, Yinhua Zhu, Changchang Cao, Dekui Jin, Peng An, Yongting Luo, Junjie Luo   +16 more
wiley   +1 more source

Nucleic Acid‐Locked Smart Carrier for Photothermal/Chemotherapy‐Amplified Immunogenic Cell Death to Enhance Systemic Antitumor Efficacy

Advanced Science, EarlyView.
Multiple therapeutic modalities combined in a synergistic way that can modulate different immune axes are demonstrated potentially effective in boosting immunotherapy. A nucleic acid‐locked smart carrier (NASC) performed as an “all‐in‐one” nanoplatform is constructed for efficient eliciting chemo‐ and photothermal‐amplified immunogenic cell death to ...
Jiayang Zhang, Tianyu Gai, Jiwei Wang, Yucai Wu, Si‐Ming Zeng, Dongyuan Zhao, Wei Li   +6 more
wiley   +1 more source

Doxorubicin selected multidrug-resistant small cell lung cancer cell lines characterised by elevated cytoplasmic Ca2+ and resistance modulation by verapamil in absence of P-glycoprotein overexpression [PDF]

, 1991
Peter Nygren, Rolf Larsson, Astrid Gruber, C. Peterson, Jonas Bergh   +4 more
openalex   +1 more source