Results 261 to 270 of about 352,925 (341)

Mucin Glycoprotein Nanoparticles Enable a Selective Antisense Therapy for Oncogenic MicroRNAs

Advanced NanoBiomed Research, EarlyView.
Mucin glycoproteins are turned into nanoparticles by employing synthetic DNA strands, which have a dual function: they stabilize the nanoparticles and act as binding sites for intracellular miRNA‐21. Thus, upon internalization into tumor cells, these mucin nanoparticles can deplete miRNA‐21 from the cytosol, which induces apoptosis in vitro and in vivo.
Ceren Kimna, Thomas Mayer, Di Zhang, Matthias Marczynski, Carolin A. Rickert, Fabio Henkel, Lennart J. K. Weiss, Friedrich C. Simmel, Yuxia Luan, Oliver Lieleg   +9 more
wiley   +1 more source

A TabNet-Based Multidimensional Deep Learning Model for Predicting Doxorubicin-Induced Cardiotoxicity in Breast Cancer Patients. [PDF]

Cancers (Basel)
Cao J, Hong X, Dong L, Jiang W, Yang W.
europepmc   +1 more source

Metabolic Signatures of Breast Cancer Subtypes and the Metabolic Impact of Chemotherapy. [PDF]

Metabolites
Mattingly A, Vickery Z, Fiorentino A, Wilson E, McCune S, Clark S, Blanchard E, Spencer J, Broom A, Ivankovic D, Pace B, Baskin L, Abenavoli L, Edenfield WJ, Chung K, Farrell CL, Hakonarson H, Boccuto L.   +17 more
europepmc   +1 more source

Comparing efficacy of neoadjuvant therapy of triple-negative breast cancer: A Bayesian network meta-regression analysis. [PDF]

Medicine (Baltimore)
Jiang Y, Zeng J, Liu J, Deng W, Kahlert UD, Tang R, Xu M, Shi W, Wang Q.   +8 more
europepmc   +1 more source

Valorization of the peel and husk of guaraná (Paullinia cupana): oil extraction, chemical composition, cytotoxicity, and antitumor potential

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Guaraná (Paullinia cupana) is a fruit native to the Amazon region. Due to its widespread use, primarily in beverages, its production has grown over the years. The seed is the only commercially valuable part of the fruit so the guaraná production chain generates byproducts, including peel, husk, and spent seed.
Leiliane do Socorro Sodré de Souza, Guilherme Teixeira de Azevedo, Eduardo Leonarski, Giovana Lima de Souza, Rafael Lopes e Oliveira, Sérgio Duvoisin Junior, Karina Cesca, Débora de Oliveira, Anderson Mathias Pereira, Ariane Mendonça Kluczkovski   +9 more
wiley   +1 more source

Limitations of Ferroptosis Inhibitors on the Doxorubicin-Induced Cardiotoxicity. [PDF]

Antioxidants (Basel)
Cha YJ, Jeon SB, Lee CJ, Kim HJ, Lee SH, Kim H, Park SH, Chen EZ, Kim JW, Park SW, Kwon C, Joung B, Lee EW, Lee S.   +13 more
europepmc   +1 more source

Chromatography of anticancer drugs [PDF]

, 2013
Cserháti, Tibor, Szőgyi, Mária
core  

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

<i>Mapping cardiac drug transport: In vitro</i> assessment of cardiac P-glycoprotein function with [¹⁸F]MC225 by using µ-engineered heart tissues. [PDF]

Eur Heart J Open
Liu W, Dannenberg M, Mossel P, Cai Z, Farinha Antunes I, Sijbesma J, Kwizera C, Cao L, van der Meer A, Passier R, Slart RHJA, Schwach V, Luurtsema G.   +12 more
europepmc   +1 more source

Model‐informed precision dosing of carboplatin in cancer patients by leveraging myelosuppression data from electronic health records

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This study aimed to develop and validate a population pharmacokinetic‐pharmacodynamic (pop‐PK‐PD) model to describe carboplatin‐induced myelosuppression in cancer patients and support dose individualization. Methods Data from 580 cancer patients treated with carboplatin at Amsterdam UMC between 2019 and 2022 were used for model ...
Alessandro De Carlo, Elena Maria Tosca, Mirjam Crul, Tim Schutte, Lia van Zuijlen, Idris Bahce, Medhat M. Said, Jan Buter, Harmen Huls, Paolo Magni, Imke Bartelink   +10 more
wiley   +1 more source