Results 161 to 170 of about 124,618 (258)

The Impact of Common Medications on Male Fertility: An Updated Systematic Review

Andrology, EarlyView.
ABSTRACT Background Compared with those of cytotoxic treatments, the potential effects of common medications on the fertility of men trying to conceive currently or planning to conceive in the future are less well described. The use of common medications may modify the gonadotropic axis, spermatogenesis, and epididymal maturation or alter male ...
Lina Jebli, Salomé Gallissian, Roxanne Barèges, Félicia Fournier, Catherine Metzler‐Guillemain, Ségolène Prades, Fanny Magnan‐Sebag, Jeanne Perrin   +7 more
wiley   +1 more source

Southern African HIV Clinicians Society guideline on doxycycline post-exposure prophylaxis to prevent bacterial sexually transmitted infections. [PDF]

South Afr J HIV Med
Gill K, Kassim S, Brink A, Delany-Moretlwe S, Mazanderani AH, Hugo J, Kufa-Chakezha T, McIntyre J, Wattrus C, Bekker LG.   +9 more
europepmc   +1 more source

Efficacy and safety of topical macrolides versus systemic tetracyclines for meibomian gland dysfunction–a systematic review and meta‐analysis

Acta Ophthalmologica, EarlyView.
Abstract Purpose To review the efficacy and safety of oral doxycycline antibiotics versus topical macrolides in the treatment of meibomian gland dysfunction (MGD). Design Systematic review and meta‐analysis. Methods A comprehensive search of PubMed, Scopus, Embase, and ClinicalTrials.gov through December 2024 identified randomised controlled trials ...
Margarita Safir, Clara C. Chan, Joshua C. Teichman, Itamar Arbel, Ruth Lapid‐Gortzak, Camiel J. F. Boon, Michael Mimouni, Dror Ben Ephraim Noyman   +7 more
wiley   +1 more source

Tigecycline versus doxycycline for scrub typhus: a preliminary randomized trial. [PDF]

Trop Med Health
Im JH, Jang S, Suh YJ, Lee D, Lee KJ, Kim J, Lee SJ, Baek JH, Park YK, Kim E, Lee SM, Lee HJ, Chung MH, Hong KW, Bae IG, Lee JS.   +15 more
europepmc   +1 more source

Systematic profiling reveals broad G protein coupling and context‐dependent modulation of cyclic AMP by the orphan receptor GPR139

British Journal of Pharmacology, EarlyView.
Background and Purpose G protein‐coupled receptors (GPCRs) are major drug targets, yet many orphan receptors remain poorly characterized. GPR139 has been implicated in CNS disorders, including schizophrenia and depression, but its signalling mechanisms remain unclear.
Boris Trapkov, Hans Bräuner, Alexander Sebastian Hauser   +2 more
wiley   +1 more source

Inhibition of the NR4A1‐mediated cell cycle checkpoint enhances hyperplastic adipogenesis and glucose homeostasis in obesity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The nuclear receptor NR4A1 is a critical node in transcriptional circuits for metabolic adaptation, yet its role in adipocyte progenitor (AP) fate and proliferation is unclear. We sought to define how NR4A1 governs early adipogenesis and adipose tissue plasticity.
Wanning Qiao, Cun Ku, G. V. Naveen Kumar, Jonathan D. Brown, Manni Wu, Chenhang Li, Jiyu Xie, Huicui Meng, Litao Sun, Tao Zhou, Dong Liang, Yiwei Li, Matthew L. Steinhauser, Yang Zhang   +13 more
wiley   +1 more source

Repurposed catechol‐O‐methyltransferase inhibitors tolcapone and entacapone preferentially suppress aggregation and seeding of P301 mutant tau in human neuronal models

British Journal of Pharmacology, EarlyView.
Background and purpose Pathogenic aggregation and propagation of seed‐competent TAU assemblies drive tauopathies. MAPT P301 mutations accelerate aggregation and enhance seed competence, yet pharmacological strategies selectively targeting these pathogenic species remain limited.
Ihor Kozlov, Yu‐Sheng Hung, Sudeep Roy, Alladi Charanraj Goud, Roman Kouřil, Yu‐Hui Wong, Viswanath Das   +6 more
wiley   +1 more source

Antibiotic therapy for pelvic inflammatory disease: a network meta-analysis. [PDF]

Cochrane Database Syst Rev
Papapanou M, Nikolakea M, Tsakiri I, Toulaki M, Syristatidi K, Siristatidis CS, Ziegelmann P, Ross J, Savaris RF.   +8 more
europepmc   +1 more source

Evolution of Bacterial Yield and Antimicrobial Resistance in Chronic Rhinosinusitis Patients in a Dedicated Sinus Centre

Clinical Otolaryngology, EarlyView.
ABSTRACT Background Antibiotics are frequently prescribed for acute exacerbations of chronic rhinosinusitis (CRS). However, antimicrobial resistance presents a challenge for the ongoing and future management of CRS patients. Objective This study aims to examine the current and past microbiological yield and antimicrobial resistance profile in a ...
Timoleon Siempis, Zhu Yeap, Shifa Ali, Carl M. Philpott   +3 more
wiley   +1 more source

Efficacy and safety of fluoroquinolones in the treatment of human brucellosis: A systematic review and meta-analysis. [PDF]

PLoS Negl Trop Dis
Mohammadi-Sartang M, Rafieipour N, Afrasiabian S, Mahmoudi R, Moradi Y, Karimi M, Servatyari K.   +6 more
europepmc   +1 more source