Results 171 to 180 of about 159,147 (288)

Autophagy Inhibition by Fangji Huangqi Decoction Enhances Tumor Immunogenicity and Potentiates PD‐1 Blockade

Cancer Science, EarlyView.
In tumor cells, MHC‐I is typically degraded through autophagy, leading to reduced antigen presentation. However, Fangji Huangqi Decoction (FJHQ), acting as an autophagy inhibitor, suppresses lysosomal acidification, which in turn inhibits the degradation of MHC‐I. This results in increased surface expression of MHC‐I on tumor cells.
Yuxiao Jiang, Shiji Zeng, Dingye Wang, Junbo Jiang, Zhenzhen Li, Jingbi Li, Dan Chen, Xu Zhao, Zheng Ying, Yuehua Deng, Qianwei Cai, Silin Mai, Jiayi Zheng, Qiaohong Yang, Fang Liu, Biaoyan Du, Jianyong Xiao, Xiaoyi Liu, Kun Wang   +18 more
wiley   +1 more source

Successful treatment of pneumonia due to <i>Mycobacterium goodii</i> in a severely underweight 45-year-old woman: case report and review of literature. [PDF]

New Microbes New Infect
Catania F, Taddei E, Palucci I, Sali M, Sanguinetti M, Torti C.   +5 more
europepmc   +1 more source

Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell Profiling

Cell Proliferation, EarlyView.
We establish a systematic framework to dissect mitochondrial function at the module level by combining targeted chemical perturbations with scRNA‐seq. This approach reveals shared and module‐specific programs linking mitochondrial activity to mito‐nuclear communication, stress response, and cell cycle, highlighting the tight coupling between ...
Hao Luo, Xiaona Yin, Hongxin He, Yaning Wang, Hongbo Zhang   +4 more
wiley   +1 more source

Pancreatic Cancer—Advances in the Last 50 Years

World Journal of Surgery, EarlyView.
S. George Barreto, Anirban Maitra, Eileen M. O'Reilly, Dushyant Sahani, Richard Zheng, Charles J. Yeo   +5 more
wiley   +1 more source

Light‐Inducible Activation of FGFR3 Facilitates Chondrocyte Maturation

Cell Proliferation, EarlyView.
Light‐inducible activation of FGFR3 induced robust activation of MAPK signaling, promoting proliferation and collagen depositon in induced chondrocytes and prevent the degeneration of osteoarthritic chondrocytes.
Mengze Sun, Yun Zhao, Yuqing Du, Yifei Fan, Kai Wang, Xiaoqing Hu   +5 more
wiley   +1 more source

A systematic review and meta-analysis of non-arsenical adulticide protocols using moxidectin and doxycycline for the treatment of adult heartworm infection in dogs. [PDF]

Curr Res Parasitol Vector Borne Dis
Santiwattanatarm T, Sakcamduang W, Kongkaew C, Anothaisintawee T, Taechikantaphat M.   +4 more
europepmc   +1 more source

National Delphi consensus on laser and energy‐based treatments for rosacea

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background Various treatments are available for rosacea, including lasers and energy‐based devices (EBDs). However, the specific role of lasers and EBDs in rosacea management remains insufficiently defined in Germany. The aim of the study was to develop a comprehensive expert consensus on the use of lasers and EBDs in the treatment of rosacea ...
Lynhda Nguyen, Nikolaus Seeber, Uwe Paasch, Martin Schaller, Claudia Borelli, Syrus Karsai, Gerd Kautz, Tanja C. Fischer, Michael Drosner, Stefan Hammes, Konstantin Feise, Christian Raulin, Martina Kerscher, Gerd Gauglitz, Jens M. Baron, Stefan W. Schneider, Katharina Herberger   +16 more
wiley   +1 more source

Case Report: First In-Human Report of Cure of Refractory <i>Mycoplasma genitalium</i> Infection With Omadacycline. [PDF]

Open Forum Infect Dis
Patel NM.
europepmc   +1 more source

Lyme Neuroborreliosis With Acute Encephalopathy Despite Early Antibiotic Therapy: A Case Report. [PDF]

Am J Case Rep
Johannesson JM, Dicks KV, Perkons ME, Cepeda Mora DF, Luedke MW, Ehrlich ME, Houk JL, McKellar MS.   +7 more
europepmc   +1 more source

Use of a 3D‐printed custom‐designed tracheostomy tube to stabilise a permanent tracheostoma in a 25‐year‐old Icelandic mare

Equine Veterinary Education, EarlyView.
Summary A 25‐year‐old Icelandic mare diagnosed with bilateral temporohyoid‐osteoarthropathy, moderate pharyngeal instability and bilateral laryngeal paralysis was presented because of intermittent stridor and dyspnoea worsening during exercise. As a previous ceratohyoidectomy had not improved these symptoms substantially, a permanent tracheostomy was ...
D. C. Debald, J. P. Schramel, E. Haltmayer, N. M. Biermann   +3 more
wiley   +1 more source