Results 11 to 20 of about 148 (82)
Enzymatic Switching Between Archaeal DNA Polymerases Facilitates Abasic Site Bypass [PDF]
Frontiers in Microbiology, 2021 Abasic sites are among the most abundant DNA lesions encountered by cells. Their replication requires actions of specialized DNA polymerases. Herein, two archaeal specialized DNA polymerases were examined for their capability to perform translesion DNA ...
Xu Feng, Sonoko Ishino, Yulong Shen
exaly +4 more sources
A Well-Conserved Archaeal B-Family Polymerase Functions as an Extender in Translesion Synthesis [PDF]
MBio, 2022 B-family DNA polymerases (PolBs) of different groups are widespread in Archaea, and different PolBs often coexist in the same organism. Many of these PolB enzymes remain to be investigated.
Sonoko Ishino +2 more
exaly +4 more sources
A Unique B-Family DNA Polymerase Facilitating Error-Prone DNA Damage Tolerance in Crenarchaeota [PDF]
Frontiers in Microbiology, 2020 Sulfolobus islandicus codes for four DNA polymerases: three are of the B-family (Dpo1, Dpo2, and Dpo3), and one is of the Y-family (Dpo4). Western analysis revealed that among the four polymerases, only Dpo2 exhibited DNA damage-inducible expression.
Xu Feng, Ruiliang Zhao, Wenyuan Han
exaly +4 more sources
DPO2 Project: telehealth to enhance the social role of physical activity in people living with COPD
Procedia Computer Science, 2021 Abstract Telehealth has been referred has an innovative solution for COPD patient treatment, minimizing the costs related with medical assistance while improving the patient care support and health outcomes. We have designed an innovative telehealth program of pulmonary rehabilitation (PR) that aims to increase long term adherence of patient to ...
Sofia Guerra-Paiva, Vitor Santos
exaly +2 more sources
Advanced Materials Technologies, Volume 8, Issue 1, January 10, 2023., 2023 A novel ECM‐based hydrogel with high oxygen carrying capacity (Oxygel) is developed and characterized, showing optimal properties for its application as cell encapsulation matrix. In parallel, a predictive model to analyze cell‐oxygen consumption within this material is designed and validated, holding great promise to increase cell engraftment success ...
Daniel A. Domingo‐Lopez +9 more
wiley +1 more source
Modeling the Effect of Hyperoxia on the Spin–Lattice Relaxation Rate R1 of Tissues
Magnetic Resonance in Medicine, Volume 88, Issue 4, Page 1867-1885, October 2022., 2022 Purpose Inducing hyperoxia in tissues is common practice in several areas of research, including oxygen‐enhanced MRI (OE‐MRI), which attempts to use the resulting signal changes to detect regions of tumor hypoxia or pulmonary disease. The linear relationship between PO2 and R1 has been reproduced in phantom solutions and body fluids such as vitreous ...
Emma Bluemke +2 more
wiley +1 more source
Journal of Magnetic Resonance Imaging, Volume 55, Issue 5, Page 1428-1439, May 2022., 2022 Background Under normal physiological conditions, the spin–lattice relaxation rate (R1) in blood is influenced by many factors, including hematocrit, field strength, and the paramagnetic effects of deoxyhemoglobin and dissolved oxygen. In addition, techniques such as oxygen‐enhanced magnetic resonance imaging (MRI) require high fractions of inspired ...
Emma Bluemke +2 more
wiley +1 more source
Biotechnology and Bioengineering, Volume 119, Issue 3, Page 881-894, March 2022., 2022 A new prototype device with small geometric footprint, the µTOM, allows monitoring of the oxygen transfer rate (OTR) in 96 deepwell microtiter plates. The device was used to monitor cultivations of common production organisms used in commercial biotechnology and research, such as Escherichia coli, Hansenula polymorpha (Ogataea angusta), and Ustilago ...
Robert Dinger +5 more
wiley +1 more source
FLASH radiotherapy with carbon ion beams
Medical Physics, Volume 49, Issue 3, Page 1974-1992, March 2022., 2022 Abstract FLASH radiotherapy is considered a new potential breakthrough in cancer treatment. Ultra‐high dose rates (>40 Gy/s) have been shown to reduce toxicity in the normal tissue without compromising tumor control, resulting in a widened therapeutic window.
Uli Andreas Weber +2 more
wiley +1 more source
A simplified empirical model to estimate oxygen relaxivity at different magnetic fields
NMR in Biomedicine, Volume 35, Issue 2, February 2022., 2022 We have compiled 28 reported empirical values of the relaxivity of oxygen and provide an empirical model for estimating the relaxivity of oxygen in water, saline, plasma, and vitreous fluids, accounting for magnetic field strength and temperature. The model agrees well (R2 = 0.93) with the data gathered from literature, ranging from 0.011 to 8.45 T and
Emma Bluemke +2 more
wiley +1 more source