Results 91 to 100 of about 19,701 (225)

Soluble Dipeptidyl Peptidase-4 Induces Fibroblast Activation Through Proteinase-Activated Receptor-2

Frontiers in Pharmacology, 2020
Fibroblasts are the chief secretory cells of the extracellular matrix (ECM) responsible for basal deposition and degradation of the ECM under normal conditions.
Shih-Yi Lee, Shih-Yi Lee, Shih-Yi Lee, Shao-Tung Wu, Yao-Jen Liang, Ming-Jai Su, Cheng-Wei Huang, Yu-Hsuan Jao, Hui-Chun Ku   +8 more
doaj   +1 more source

Timing and duration of glucagon‐like peptide‐1 receptor agonist use and risk of nonarteritic anterior ischaemic optic neuropathy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To investigate the association between glucagon‐like peptide‐1 receptor agonist (GLP‐1RA) use and nonarteritic anterior ischaemic optic neuropathy (NAION) in type 2 diabetes, examining treatment recency and cumulative duration. Methods This nationwide registry‐based nested case–control study utilizedz Danish health registries (1996 ...
Siar Niazi, Filip Gnesin, Baker Nawfal Jawad, Zia Niazi, Puriya Daniel Wuertz Yazdanfard, Anne P. Toft‐Petersen, Kathrine Kold Sørensen, Amani Meaidi, Yousif Subhi, Christian Torp‐Pedersen   +9 more
wiley   +1 more source

A siRNA mediated hepatic dpp4 knockdown affects lipid, but not glucose metabolism in diabetic mice.

PLoS ONE, 2019
Systemic inhibition of dipeptidyl peptidase 4 (dpp4) represents an effective and established treatment option for type 2 diabetes (T2D). The current study investigated in mice if a liver selective knock-down of dpp4 by therapeutic siRNAs could be a novel,
Sven Wolfgang Görgens, Kerstin Jahn-Hofmann, Dinesh Bangari, Sheila Cummings, Christiane Metz-Weidmann, Uwe Schwahn, Paulus Wohlfart, Matthias Schäfer, Maximilian Bielohuby   +8 more
doaj   +1 more source

Serum FGF23 and DPP4 Levels as Biomarkers for Coronary Artery Disease Severity in Type 2 Diabetic Patients with Coronary Heart Disease [PDF]

Xuanli Zhong, Zhanyun Liang, Haiming Liao, Yuanyuan Zhan, Ge Li, Huanping Wu, Jinying Li Department of Endocrinology, The Affiliated Shunde Hospital of Jinan University, Foshan, Guangdong, 528300, People’s Republic of ChinaCorrespondence: Jinying Li ...
Li G, Li J, Liao H, Liang Z, Zhong X, Zhan Y, Wu H   +6 more
core  

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Identification and Characterization of Prokaryotic Dipeptidyl-Peptidase 5 from Porphyromonas gingivalis [PDF]

, 2014
Porphyromonas gingivalis, a Gram-negative asaccharolytic anaerobe, is one of the major causative organisms of chronic periodontitis. The bacterium utilizes amino acids as energy and carbon sources, and incorporates them mainly as dipeptides. Therefore, a
Nakayama, Koji, Ohara-Nemoto, Yuko, Ono, Toshio, Tetsuo, Fumi, Nemoto, Takayuki K., Yanase, Amie, Konishi, Kiyoshi, Kobayakawa, Takeshi, Rouf, Shakh M. A., Kimura, Shigenobu, Shimoyama, Yu, Saiki, Keitarou, Naito, Mariko   +12 more
core   +1 more source

Evaluation of a secondary care multidisciplinary clinic for adults with early‐onset type 2 diabetes at high risk in Leicester, Leicestershire and Rutland

Diabetic Medicine, EarlyView.
Abstract Background Clinical services for adults with early‐onset type 2 diabetes (EOT2D) are in urgent need of improvement. Methods We evaluated a multi‐disciplinary clinic for individuals with EOT2D at high risk (HbA1c >9%/triglyceride >20 mmol/L), providing 2–3 flexibly arranged consultations per individual between March 2024 and September 2025 ...
Jonathan Goldney, Malak Hamza, Priscilla Sarkar, Harriet Morgan, Nicole Green, James Ridgeway, Victoria Alabraba, Laura Willcocks, Krupali Chandracant, Kashmala Javed, Rhys O'Callaghan, Finley Turner, Samuel Seidu, Claire L. Meek, Melanie J. Davies   +14 more
wiley   +1 more source

ARV p17 supresses angiogenesis by promoting DPP4 secretion

, 2021
ARV p17 supresses angiogenesis by promoting DPP4 secretionARV p17 supresses angiogenesis by promoting DPP4 ...
Manocha, Ekta
core  

Genetic and Clinical Determinants of Variation in Drug Response in Type 2 Diabetes: Insights From the Scottish and UK Biobank Cohorts

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Objective Treatment response in type 2 diabetes (T2D) varies widely among individuals. This study aimed to quantify the contributions of clinical characteristics and genetic predisposition as measured through partitioned polygenic risk scores (pPRS) to variation in glycemic response to glucose‐lowering therapies.
S. Garg, R. Kitchen, R. Gupta, L. Donnelly, E. R. Pearson   +4 more
wiley   +1 more source

Identification of senescent cell surface targetable protein DPP4

, 2017
Senescent cell accumulation in aging tissues is linked to age-associated diseases and declining function, prompting efforts to eliminate them. Mass spectrometry analysis revealed that DPP4 (dipeptidyl peptidase 4) was selectively expressed on the surface
Chikao Morimoto, Kyoung Mi Kim, Kei Ohnuma, Arya Biragyn, Sandip K. Basu, Monica Bodogai, Fred E. Indig, Peter F. Johnson, Xiaoling Yang, Kotb Abdelmohsen, Myriam Gorospe, Jennifer L. Martindale, Ji Heon Noh   +12 more
core   +1 more source