Results 101 to 110 of about 19,701 (225)

Oral Semaglutide in Routine Clinical Practice: 24‐Month Real‐World Effectiveness, Persistence and Safety in Adults With Type 2 Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Real‐world long‐term data on oral semaglutide are limited. We evaluated its 24‐month effectiveness, persistence, and safety in adults with type 2 diabetes (T2D). Materials and Methods This retrospective real‐world study included 232 adults with T2D initiating oral semaglutide at an Italian diabetes clinic.
Maria Pompea Antonia Baldassarre, Giulia Di Dalmazi, Federica Carrieri, Giorgia Centorame, Luigi Piacentino, Sara Coluzzi, Gloria Formoso   +6 more
wiley   +1 more source

Prognostic and Therapeutic Significance of DPP4 in SMARCA4-Deficient Non–Small Cell Lung Cancer

Technology in Cancer Research & Treatment
Introduction SMARCA4-deficient NSCLC is an aggressive subtype lacking robust biomarkers and therapeutic targets. To define the expression pattern and clinical significance of DPP4 in SMARCA4-dNSCLC and explore whether DPP4 may represent a therapeutic ...
Chaopeng Chen, Zebin Zhong, Xiaoling Luo, Weiping Dai, Lujian Xu, Wenping Cai, Zhibin Xu, Guolian Liang, Lijuan Pang   +8 more
doaj   +1 more source

Serum‐derived microribonucleic acids as potential novel biomarkers for slowly progressive type 1 diabetes mellitus

Journal of Diabetes Investigation, EarlyView.
This study evaluated serum miRNAs as biomarkers in adult patients with SPIDDM. Serum miRNAs were measured at the time of SPIDDM (probable) diagnosis, and miR‐150‐5p was inversely associated with CPI at the last outpatient visit, suggesting its potential utility for predicting subsequent insulin secretory decline.
Hideyuki Okuma, Takahiro Tsutsumi, Masashi Ichijo, Tetsuro Kobayashi, Kyoichiro Tsuchiya   +4 more
wiley   +1 more source

Letko 2018 alignment - bat DPP4

, 2018
Nucleotide sequences of DPP4, the receptor for MERS-CoV, from 16 different bat species were translated and aligned as amino acid sequences using ...
Letko, M (via Mendeley Data)
core   +1 more source

Discontinuation of Glucagon‐Like Peptide‐1 Receptor Agonists After Bowel Obstruction or Ileus: A Nationwide, Real‐World, Database Study

Journal of Evidence-Based Medicine, EarlyView.
ABSTRACT Objective Although concerns have been raised that glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) may increase the risk of bowel obstruction or ileus, evidence remains inconclusive. In this context of uncertainty, we examined the frequency and determinants of GLP‐1RA discontinuation after hospitalization for bowel obstruction/ileus ...
Yuichiro Matsuo, Akira Okada, Takashi Sakamoto, Hideo Yasunaga   +3 more
wiley   +1 more source

Supplemental information Comparative Binding Study of Gliptins to Bacterial DPP4-like Enzymes for the Treatment of Type 2 Diabetes Mellitus (T2DM)

Table S1.Comparative analysis of residues within binding pocket sections across 5 DPP4 homologs and the human variant. Colors visually represent aminoacids properties: pink indicates non-polar aliphatic residues, green represents polar uncharged residues,
Sanz Herranz, Yolanda, Barigye, Stephen J., Serrano-Candelas, Eva, Gozalbes, Rafael, Carpio, Laureano E., Benítez-Páez, Alfonso, Olivares, Marta   +6 more
core   +1 more source

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

, 2017
International audienceFerroptosis is a form of regulated cell death that may facilitate the selective elimination of tumor cells. The tumor suppressor p53 (TP53) has been demonstrated to promote ferroptosis via a transcription-dependent mechanism.
Tang, Daolin, Herbert J. Zeh, III, Lotze, Michael T., Shan Zhu, Lin Zhang, Rui Kang, Zhong, Meizuo, Yong Fan, Yangchun Xie, Song, Xinxin, Sun, Xiaofang, Kroemer, Guido, Meizuo Zhong, Billiar, Timothy R., Xie, Yangchun, Liu, Jinbao, Kang, Rui, Xinxin Song, Daolin Tang, Zhang, Lin, Fan, Yong, Hua Yuan, Timothy R. Billiar, Yuan, Hua, Zeh Iii, Herbert J., Jinbao Liu, Zhu, Shan, Herbert J. Zeh, Xiaofang Sun, Guido Kroemer, Michael T. Lotze   +30 more
core   +1 more source

Cell Therapy for Periodontal, Soft‐Tissue, and Craniofacial Regeneration

Journal of Periodontal Research, EarlyView.
The clinical translation of mesenchymal stem/stromal cells (MSCs) represents a major advancement in dentistry, especially for periodontal, soft‐tissue, and craniofacial regeneration. However, several challenges remain to be addressed, including the absence of standardised protocols, limited scalability, regulatory hurdles, a lack of well‐controlled ...
Kamal Mustafa, Shuntaro Yamada, Nerea Sanchez, Magdalena Mayol, Cecilie Gjerde, Mariano Sanz   +5 more
wiley   +1 more source

Effect of Slfn3 silencing on Dpp4 expression and activity.

, 2013
Exposure of the mucosa to Ad-GFP-Slfn3 increased transcript level of Dpp4 (A, n = 6 ...
Marc D. Basson (482537), Andrea Amalfitano (208378), Lisi Yuan (482533), Lyudmyla Kunovska (482535), Kelian Sun (482534), Pavlo L. Kovalenko (482532), Sergey Seregin (482536)   +6 more
core   +1 more source

Epigenomic Cascades Across Organs in Metabolic Dysfunction–Associated Steatotic Liver Disease: New Therapeutic Horizons

Obesity Reviews, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang, Zhongyu Huang, Sanchun Tan, Fengxia Liang, Li Chen   +4 more
wiley   +1 more source