Results 131 to 140 of about 19,701 (225)

Ferroptosis: Newly Emerged Regulator for Human Disease

MedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao, Lin Ye, Tianqi Jiang, Mengyuan Liu, Yuxia Zhou   +4 more
wiley   +1 more source

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

Effect of the DPP4 Inhibitor Sitagliptin on Ferroptosis in Epilepsy

Journal of Integrative Neuroscience
Background: Epilepsy, a significant neurological condition marked by the occurrence of repeated seizures, continues to pose a substantial health challenge. Previous studies have indicated that Dipeptidyl Peptidase-4 (DPP4) inhibitors may possess antiepileptic properties.
Jincheng Guo, Fei Wang, Lin Li, Baohua Hou   +3 more
openaire   +2 more sources

Deciphering the Mechanisms of Statin–Ezetimibe Drug Combinations Using Boolean Logical Modeling and Transcriptomic Data

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT Drug Combinations offer increased therapeutic efficacy and reduced toxicity compared with single agents. Understanding a drug combination's mechanisms of action (MoA) can provide important insights into therapeutic efficacy. The MoA of many FDA‐approved drugs, however, often remains unclear.
Rui‐Sheng Wang, Matteo Pedrelli, Osman Ahmed, Garagnani Paolo, Paolo Parini, Joseph Loscalzo   +5 more
wiley   +1 more source

siRNA-mediated knock-down of hepatic dpp4 in db/db mice.

, 2019
(A) Schematic illustration of the study design. (B, C and D) Liver samples were taken after study termination at day 30. (B) dpp4 mRNA expression was analyzed by real-time PCR after indicated treatment. (C) Quantification of dpp4 protein abundance.
Sven Wolfgang Görgens (8072297), Maximilian Bielohuby (158339), Christiane Metz-Weidmann (8072303), Paulus Wohlfart (3455771), Sheila Cummings (8072300), Matthias Schäfer (283944), Dinesh Bangari (349019), Kerstin Jahn-Hofmann (3332715), Uwe Schwahn (457324)   +8 more
core   +1 more source

SGLT2 Inhibitors Are Associated With Suppression of the Sema3A/NRP1/Plexin‐A1 Signaling Axis in Postmenopausal Women With Type 2 Diabetes: Evidence From Propensity Score‐Matched Analysis

Journal of Diabetes, Volume 18, Issue 9, September 2026.
Propensity score‐matched comparison of 23 SGLT2 inhibitor users and 23 non‐users revealed that SGLT2 inhibitor use was associated with significantly lower Neuropilin‐1 (NRP1) levels (74.25 vs. 87.61 ng/mL; p = 0.015) and a higher Sema3A/NRP1 ratio (0.14 vs.
Sertas Erarslan, Burcu Cosgun Bora
wiley   +1 more source

Immature Neutrophil Phenotype and Enhanced Myeloperoxidase in Male Patients With Chronic Kidney Disease and Cardiovascular Comorbidity

Acta Physiologica, Volume 242, Issue 9, September 2026.
ABSTRACT Aim Patients with chronic kidney disease (CKD) have an increased cardiovascular risk. Since neutrophils and neutrophil‐borne proteins contribute to cardiovascular disease, we analyzed the neutrophil phenotype in patients with CKD who presented with a spectrum of cardiovascular comorbidities.
Sonja Vondenhoff, Alessandra Antwerpen, Carolina Victoria Cruz Junho, Philipp Martin, Sina Hourtz, Jinmi Zou, Berkan Kurt, Carolin Haas, Susanne Fleig, Corinna Schulte, Jane Lauxen, Martina Wessiepe, Ulrike Späte‐Schulze, Rafael Kramann, Jürgen Floege, Oliver Soehnlein, Joachim Jankowski, Claudia Goettsch, Yvonne Döring, Florian Kahles, Nikolaus Marx, Constance C. F. M. J. Baaten, Heidi Noels   +22 more
wiley   +1 more source

Nationwide Real‐World Retrospective Study of Oral Semaglutide Use in Adults Living With Type 2 Diabetes in Finland

Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 7814-7824, September 2026.
ABSTRACT Aim This Finnish nationwide retrospective 'real‐world' study evaluated the effects of oral semaglutide on glycaemic control, body weight, lipid profile, and liver enzymes in adults living with type 2 diabetes (T2D) and naïve to any GLP‐1 receptor agonists in Finland.
Atte Vaden, Mari Lahelma, Lalli Nurmi, Eija Heikkilä, Hannu Vessari, Hanne Luoto, Tero Saukkonen, Leo Niskanen   +7 more
wiley   +1 more source

DPP4 inhibition prevents AKI

Oncotarget, 2017
Reichetzeder, Christoph, Hocher, Berthold   +1 more
openaire   +2 more sources

DPP4 Gene [PDF]

, 2020
openaire   +1 more source