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DPP4/CD32b/NF-κB Circuit: A Novel Druggable Target for Inhibiting CRP-Driven Diabetic Nephropathy
Molecular Therapy, 2021Patrick Ming-Kuen Tang +2 more
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Targeting CD26/DPP4 in organ fibrosis
CD26/DPP4 is an exopeptidase that is expressed on the cell surface of many organs but is also present in a circulating soluble form. Beyond its enzymatic and co-stimulatory activity, CD26/DPP4 is involved in the pathogenesis of chronic fibrosis across many organ diseases such as liver cirrhosis, kidney failure, and lung fibrosis, but CD26/DPP4 has alsoWolfgang Jungraithmayr +3 more
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DPP4 reduces proinflammatory cytokine production in human rheumatoid arthritis synovial fibroblasts
Journal of Cellular Physiology, 2021Chien-Kuo Han +2 more
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Angiogenesis is promoted by exosomal DPP4 derived from 5-fluorouracil-resistant colon cancer cells
Cancer Letters, 2021Xin Dong, Bangwei Cao
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Teneligliptin – The newest DPP4 inhibitor
International Journal of Pharma and Bio Sciences, 2017DR. MAYURESH KIRAN +2 more
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Epigenetic regulation of hepatic DPP4
Diabetologie und Stoffwechsel, 2017S Saussenthaler +8 more
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Defining a Role for DPP4 in Inflammation and Atherosclerosis
Atherosclerosis is an accumulation of lipid-rich plaques within arteries and a leading cause of death worldwide. Chronic low-grade inflammation is characteristic of atherosclerosis, where monocytes and macrophages play a critical role in the progression or regression of plaque.openaire +1 more source