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Retraction Notice to: DPP4/CD32b/NF-κB Circuit: A Novel Druggable Target for Inhibiting CRP-Driven Diabetic Nephropathy. [PDF]
Mol TherMing-Kuen Tang P +6 more
europepmc +1 more source
DPP4/CD32b/NF-κB Circuit: A Novel Druggable Target for Inhibiting CRP-Driven Diabetic Nephropathy. [PDF]
Mol TherMing-Kuen Tang P +6 more
europepmc +1 more source
DPP4 inhibitors for diabetes—What next?
Biochemical Pharmacology, 2008 With vildagliptin and sitagliptin on the market for the treatment of type 2 diabetes, dipeptidyl peptidase 4 (DPP4, EC 3.4.14.5) research has entered a new era. Scientists aim to uncover the broader pharmacological profile of DPP4 inhibitors and search for therapeutic opportunities outside diabetes.
Lambeir, Anne-Marie +2 more
openaire +4 more sources
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Life Sciences, 2011
We previously reported that dipeptidyl peptidase IV (DPP4)-deficient rats were susceptible to dyslipidemia induced by streptozotocin (STZ). Hence, it is suggested that DPP4 is important for lipid metabolism.In this study, to verify the role of DPP4 in the development of dyslipidemia, we carried out a microarray analysis of the livers of STZ-treated ...
Youichi Sato +2 more
exaly +3 more sources
We previously reported that dipeptidyl peptidase IV (DPP4)-deficient rats were susceptible to dyslipidemia induced by streptozotocin (STZ). Hence, it is suggested that DPP4 is important for lipid metabolism.In this study, to verify the role of DPP4 in the development of dyslipidemia, we carried out a microarray analysis of the livers of STZ-treated ...
Youichi Sato +2 more
exaly +3 more sources
Science Translational Medicine, 2011 In patients with metabolic syndrome, human visceral fat secretes an adipokine DPP4 that impairs insulin signaling in muscle, potentially contributing to insulin resistance.
Mickie H. Cheng
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Role of Dipeptidyl Peptidase-4 (DPP4) on COVID-19 Physiopathology [PDF]
Biomedicines, 2022 DPP4/CD26 is a single-pass transmembrane protein with multiple functions on glycemic control, cell migration and proliferation, and the immune system, among others.
Alba Sebastián-Martín +2 more
exaly +2 more sources
The protective role of DPP4 inhibitors in atherosclerosis
European Journal of Pharmacology, 2020Diabetes is a chronic non-communicable disease whose incidence continues to grow rapidly, and it is one of the most serious and critical public health problems. Diabetes complications, especially atherosclerosis-related chronic vascular complications, are a serious threat to human life and health.
Hengdao, Liu +9 more
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Is DPP4 activity increased in PCOS?
Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2018Dipeptidyl peptidase-4 (DPP4) is an adipokine with greater expression in visceral fat and related with insulin resistance (IR). Polycystic ovary syndrome (PCOS) is also associated with IR. Our study aims to evaluate DPP4 activity in PCOS.Thirty PCOS patients were compared to 28 healthy women.
Letícia Dinis da C, Braga +4 more
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DPP4 Inhibitors: a new approach in diabetes treatment
Advances in Therapy, 2008The role of dipeptidyl peptidase-IV (DPP4) as both a regulatory enzyme and a signalling factor has been evaluated and described in many studies. DPP4 inhibition results in increased blood concentration of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP).
John, Doupis, Aristidis, Veves
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Pharmacological DPP4 inhibition for the prevention of vascular diseases
International Journal of Cardiology, 2016Yang et al. have broadly summarized potential DPP4-dependentmolecular mechanisms for the development of atherosclerosis [1]. In our hands, vascular protective effects based on pharmacological inhibition of DPP4 can be seen in acute vascular injury as well as during initiation of atherosclerosis [2,3].
C, Brenner, W M, Franz
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