Results 201 to 210 of about 19,701 (225)

Synthesis, SAR, and atropisomerism of imidazolopyrimidine DPP4 inhibitors

Bioorganic & Medicinal Chemistry Letters, 2010
The synthesis and SAR of aminomethyl-substituted imidazolopyrimidine DPP4 inhibitors bearing varied pendant aryl groups is described. Compound 1, which exists as a separable mixture of non-interconvertible atropisomers was used as the starting point for investigation.
Stephen P, O'Connor, Ying, Wang, Ligaya M, Simpkins, Robert P, Brigance, Wei, Meng, Aiying, Wang, Mark S, Kirby, Carolyn A, Weigelt, Lawrence G, Hamann   +8 more
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Soluble DPP4 promotes hepatocyte lipid accumulation via SOX2-SCD1 signaling and counteracts DPP4 inhibition

Biochemical and Biophysical Research Communications
Dipeptidyl peptidase-4 (DPP4), a well-known target of antidiabetic therapy, is implicated in steatotic liver disease. However, its role in hepatic lipid metabolism, particularly the distinct functions of soluble DPP4 (sDPP4) and membrane-bound DPP4 (mbDPP4), remains unclear.
Chen Shen, Ha Ram Oh, Young Ran Park, Shinyoung Oh, Ji Hyun Park   +4 more
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Incretin effect: GLP-1, GIP, DPP4

Diabetes Research and Clinical Practice, 2011
The term incretin effect was used to describe the fact that oral glucose load produces a greater insulin response than that of an isoglycemic intravenous glucose infusion. This difference has been attributed to gastrointestinal peptides GLP-1 and GIP. Since incretin effect is reduced in subjects with type 2 diabetes, despite GLP-1 activity preservation,
openaire   +2 more sources

DPP4

RCSB Protein Data Bank, 2017
Jennifer Jiang, Sutapa Ghosh
openaire   +1 more source

Bullous pemphigoid and DPP4 inhibitors

Medicina Clínica (English Edition), 2019
Rubén, García Castro, Elena, Godoy Gijón, Ana María, González Pérez, Concepción, Román Curto   +3 more
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Targeting CD26/DPP4 in organ fibrosis

CD26/DPP4 is an exopeptidase that is expressed on the cell surface of many organs but is also present in a circulating soluble form. Beyond its enzymatic and co-stimulatory activity, CD26/DPP4 is involved in the pathogenesis of chronic fibrosis across many organ diseases such as liver cirrhosis, kidney failure, and lung fibrosis, but CD26/DPP4 has also
Wolfgang Jungraithmayr, Isabelle Moneke, Birte Ohm, Ingrid De Meester   +3 more
openaire   +1 more source

DPP4 reduces proinflammatory cytokine production in human rheumatoid arthritis synovial fibroblasts

Journal of Cellular Physiology, 2021
Ju-Fang Liu, Yuan-Li Huang, Jui-Chieh Chen   +2 more
exaly  

Angiogenesis is promoted by exosomal DPP4 derived from 5-fluorouracil-resistant colon cancer cells

Cancer Letters, 2021
Bangwei Cao
exaly  

Targeting cluster of differentiation 26 / dipeptidyl peptidase 4 (CD26/DPP4) in organ fibrosis

British Journal of Pharmacology, 2023
Birte Ohm
exaly  

Epigenetic regulation of hepatic DPP4

Diabetologie und Stoffwechsel, 2017
S Saussenthaler, C Baumeier, A Kammel, M Canouil, S Lobbens, F Pattou, P Froguel, RW Schwenk, A Schürmann   +8 more
openaire   +1 more source