Results 71 to 80 of about 2,512 (255)

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

An Examination of Lexical Choices in Slovene Translations of British and American Drama

open access: yesELOPE, 2005
The article examines lexical choices preferred by a noted Slovene translator of dramatic texts. It is based on the assumption that in spite of the fact that lexical choices offer much greater freedom in translation than, for instance, grammatical ...
Darja Hribar
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Gertrudis Gómez de Avellaneda, adaptadora teatral [PDF]

open access: yesÇédille: Revista de Estudios Franceses, 2006
Gertrudis Gómez de Avellaneda, connoisseur of French literature, adapted for the Spanish scene three current dramas from the original versions of Augier, Maquet-Dumas and Lemoine-Scribe. Avellaneda did not restrict herself to the translation of the texts
Alfonso Saura
doaj  

The Fifth Slovene Hamlet: Return to Tradition?

open access: yesMulticultural Shakespeare, 2017
Over the nearly two centuries that Hamlet has been a fixture of the Slovene cultural firmament, the complete text has been translated five times, mostly by highly esteemed figures of Slovene literature and literary translation.
Marija Zlatnar Moe
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Stylizacja na język potoczny w tłumaczeniu kanadyjskiej dramaturgii mniejszościowej na przykładzie polskiej wersji sztuki La Défaite Georges’a Bugneta

open access: yesMiędzy Oryginałem a Przekładem, 2015
Colloquial stylization in French‑Canadian minority theatre: The case of Georges Bugnet’s La Défaite and its translation into Polish Recourse to „oralité” in written texts, which is specific to the Francophone communities in Canada, poses a challenge ...
Małgorzata Czubińska
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

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