Results 61 to 70 of about 2,504 (255)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Author’s Epithet in A. Casona’s Dramas: Features of Functioning and Problem of Translation
Научный диалог, 2018 The article is devoted to art techniques most typical to A. Casona’s idiostyle - the author’s epithet - in the aspect of translation into Russian. The term “ author’s epithet ” means an unexpected, non-reproducible combination enriching the writer’s ...
V. V. Shchepalina
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Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
La Fedra di Seneca-Sanguineti: rilettura di una traduzione per la messinscena
Erga-Logoi, 2014 The purpose of this study is to fill a gap about Edoardo Sanguineti’s translations in the current bibliography. Despite the fact that Friedmar Apel’s method brings a sweeping change to research in the field of translation studies and many works about ...
Sara Bandiera
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Engagement et désengagement dans les paratextes des traductions théâtrales du XVIe siècle
Revue Italienne d'Etudes FrançaisesThis essay examines the paratexts (such as prefaces, dedicatory epistles, forewords, and more) of several drama translations that were published in France during the 16th century, in order to prove that, even though most of these texts were engaged and ...
Daniele Speziari
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FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Brian Friel as Linguist, Brian Friel as Drama Translator
Studi Irlandesi, 2014 The aim of this paper is to demonstrate how linguistic and translation issues have always been Friel’s main concerns. First of all, the language question in Ireland will be investigated in its multi-faceted implications. In particular, Tom Paulin’s A New
Monica Randaccio
doaj +1 more source