Results 91 to 100 of about 1,849,126 (285)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Whitehaven Dramatic Club presents "A Fisherman's Luck"
, 1896 Program for the production of "A Fisherman's Luck" by the White Haven Dramatic Club. Presented at the Court-House, Hernando, Mississippi on Tuesday, Dec. 29th, 1896, 8 o'clock.
White Haven Dramatic Club
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Sinais de CenaRecensão crítica ao livro As Páginas Arrancadas, de Luiz Francisco Rebello.
Eugénia Vasques
doaj +1 more source
, 2011 Previous studies show that infants undergo a perceptual reorganization (PR) in their sensitivity to lexical tones between 6 and 9 months in the first year of life [Mattock & Burnham, 1; Mattock, Molnar, Polka & Burnham, 2].
Kager, René, Liu, Liquan (R18335)
core
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Ousar a fragilidade das matérias, celebrar os vínculos
Sinais de CenaCrítica ao Festival Internacional de Marionetas do Porto FIMP ...
Catarina Firmo
doaj +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Festival END: una experiencia intercalada falada
Sinais de CenaCrítica ao Festival END 2024.
Francisca Meleiro +1 more
doaj +1 more source