Results 71 to 80 of about 111,387 (297)

Representing dramatic features of stories through an ontological model

, 2011
. In this paper we present a novel ontology-based model for the representation of the dramatic features of narrative media (video, text, audio, etc.), focused on the notions of the character's motivated actions.
Mario Cataldi, Rossana Damiano, Vincenzo Lombardo, Pizzo, Antonio, Lombardo, Vincenzo, Cataldi, Mario, Damiano, Rossana, Antonio Pizzo   +7 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Various aspects of realization of the plot “liberation from the oppressors” in russian fairytale drama of 1920-1940’s (on the example of the plays “Dragon” by E.L. Shvarts, “Three Fat Men” by Yu.K. Olesha and “The Town of Masters, or The Tale about Two Humpbacks” by T.G. Gabbe)

RUDN Journal of Studies in Literature and Journalism, 2014
In this paper on the example of three plays written in 1920-40s., the features of realization of the motive of “liberation from the oppressors” widely used in Russian Soviet literature for children is discussed.
A I Safuanova
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Diluted representation of Shoah and Education: the (tele)dramatic model in Jayme Monjardim’s Olga (2004)

Travessias, 2017
Piece of work on the problems of representation of Shoah (“Holocaust”) in film works, based on theoretical notions such as fictional resistance of the trauma, memory, and testimony.
Márcio Henrique Muraca
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Komično v umetnosti za otroke in mlade: kako 93 otroci in mladi dojemajo prvine humorja in se nanje odzivajo

Amfiteater
Komedija in elementi komičnega v umetnosti za otroke in mlade lahko segajo od šaljivega humorja do prefinjene duhovitosti, lahko so namenjeni zgolj zabavi, lahko pa služijo tudi kot način, kako mlajšemu občinstvu posredovati pomembna sporočila, in ga ...
Martina Peštaj, Benjamin Zajc
doaj   +1 more source

Theatre as Representation (TAR) and the Teaching of a Graduate Administration of Inclusive Schools Course

, 2013
Based on continuing research in Theatre as Representation (TAR), this paper examines and explores an application of a TAR based dramatic scenario that expands each participant’s creative awareness of both content and participation in an administration of
Meyer, Mathew, Young, David
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source