Results 61 to 70 of about 111,387 (297)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

TRA ARTE E ATTIVISMO, ISTRUZIONI PER L'USO 1.0. Catalogo della mostra (Pisa, 2011)

Connessioni remote, 2020
Giacomo Verde - Tra arte e attivismo. Istruzioni per l'uso 1.0 Catalogo della mostra a cura di Silvana Vassallo e Francesca Maccarrone (Pisa, Studio Gennai, 2011)
Vincenzo Sansone
doaj   +1 more source

Hierarchical PNF Networks - A Temporal Model of Events for the Representation and Dramatization of Storytelling [PDF]

2009 VIII Brazilian Symposium on Games and Digital Entertainment, 2009
Storytelling is an important feature in games and also other types of (semi) automated entertainment systems such as machinima and digital-TV. The majority of the current research in storytelling use precedence-based directed acyclic graphs, or even linear sequences, to model the ordering of events in a story.
Erick Baptista Passos, Anselmo Antunes Montenegro, Esteban Walter Gonzalez Clua, Cesar Tadeu Pozzer, Flávio Soares Corrêa da Silva   +4 more
openaire   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

MANIF(Ǝ)STO REO DADA. Testo del Collettivo dada Boom

Connessioni remote, 2020
manif(Ǝ)stO reo dadaista Messaggio dal Collettivo Dada Boom del Varignano del pianeta Terra alle sorelle, ai fratelli e agli zii degli spazi intergalattici.
Vincenzo Sansone
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

“Voglio la vodka!”. Breve storia di un dramma della gelosia e della malinconia

Il castello di Elsinore
Con il presente articolo si intende ricostruire il contesto storico-culturale che permise ad Ardengo Soffici di elaborare il manoscritto, sino ad oggi rimasto inedito, dal titolo «Voglio la Vodka!» Tre tempi.
Ruben Donno
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Women who wreak havoc: a new perspective on early modern drama, 1603-1642 [PDF]

, 2004
This doctoral thesis looks anew at the representation of women in the non-Shakespearean plays of early Stuart England (1603-1642). The chapters progress chronologically, locating common themes of the period, which I analyse independently in each chapter,
Sutherland, Julie
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