Results 61 to 70 of about 106,525 (255)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Various aspects of realization of the plot “liberation from the oppressors” in russian fairytale drama of 1920-1940’s (on the example of the plays “Dragon” by E.L. Shvarts, “Three Fat Men” by Yu.K. Olesha and “The Town of Masters, or The Tale about Two Humpbacks” by T.G. Gabbe)

RUDN Journal of Studies in Literature and Journalism, 2014
In this paper on the example of three plays written in 1920-40s., the features of realization of the motive of “liberation from the oppressors” widely used in Russian Soviet literature for children is discussed.
A I Safuanova
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Diluted representation of Shoah and Education: the (tele)dramatic model in Jayme Monjardim’s Olga (2004)

Travessias, 2017
Piece of work on the problems of representation of Shoah (“Holocaust”) in film works, based on theoretical notions such as fictional resistance of the trauma, memory, and testimony.
Márcio Henrique Muraca
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Komično v umetnosti za otroke in mlade: kako 93 otroci in mladi dojemajo prvine humorja in se nanje odzivajo

Amfiteater
Komedija in elementi komičnega v umetnosti za otroke in mlade lahko segajo od šaljivega humorja do prefinjene duhovitosti, lahko so namenjeni zgolj zabavi, lahko pa služijo tudi kot način, kako mlajšemu občinstvu posredovati pomembna sporočila, in ga ...
Martina Peštaj, Benjamin Zajc
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Igrske akcije v novomedijskih umetniških delih

Amfiteater
Članek izhaja iz teorije video iger Alexandra R. Gallowaya. Gre za analizo medija, utemeljenega v akcijah, in njegovih specifik. Igrske akcije sistema igre izvajata upravljavec in stroj, odvijajo pa se tako v diegetskem kot nediegetskem prostoru igre. S
Narvika Bovcon
doaj   +1 more source