Results 61 to 70 of about 1,903,334 (287)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Proportional representation review

, 1914
Includes supplements.Includes supplements.Mode of access: Internet.Organ of the Proportional Representation League (called, 1914-1920, American Proportional Representation League).The Proportional representation review (v. 1-3) was issued in Chicago from
American Proportional Representation League., Proportional Representation League.   +1 more
core  

Representing dramatic features of stories through an ontological model

, 2011
. In this paper we present a novel ontology-based model for the representation of the dramatic features of narrative media (video, text, audio, etc.), focused on the notions of the character's motivated actions.
Mario Cataldi, Rossana Damiano, Vincenzo Lombardo, Pizzo, Antonio, Lombardo, Vincenzo, Cataldi, Mario, Damiano, Rossana, Antonio Pizzo   +7 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Deacon : presented by the Anderson Amateur Dramatic Society, Anderson, Tex., Friday, March 25.

, 1892
A playbill for the play ''The Deacon'' put on by the Anderson Amateur Dramatic Society.Playbill. Date of publication suggested by vendor, using perpetual calendar and the fact that The Deacon was written by Horace C. Dale in 1892.
Anderson Amateur Dramatic Society (Anderson, Tex.)
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Various aspects of realization of the plot “liberation from the oppressors” in russian fairytale drama of 1920-1940’s (on the example of the plays “Dragon” by E.L. Shvarts, “Three Fat Men” by Yu.K. Olesha and “The Town of Masters, or The Tale about Two Humpbacks” by T.G. Gabbe)

RUDN Journal of Studies in Literature and Journalism, 2014
In this paper on the example of three plays written in 1920-40s., the features of realization of the motive of “liberation from the oppressors” widely used in Russian Soviet literature for children is discussed.
A I Safuanova
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Diluted representation of Shoah and Education: the (tele)dramatic model in Jayme Monjardim’s Olga (2004)

Travessias, 2017
Piece of work on the problems of representation of Shoah (“Holocaust”) in film works, based on theoretical notions such as fictional resistance of the trauma, memory, and testimony.
Márcio Henrique Muraca
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source