Results 81 to 90 of about 690,851 (296)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Various aspects of realization of the plot “liberation from the oppressors” in russian fairytale drama of 1920-1940’s (on the example of the plays “Dragon” by E.L. Shvarts, “Three Fat Men” by Yu.K. Olesha and “The Town of Masters, or The Tale about Two Humpbacks” by T.G. Gabbe)

RUDN Journal of Studies in Literature and Journalism, 2014
In this paper on the example of three plays written in 1920-40s., the features of realization of the motive of “liberation from the oppressors” widely used in Russian Soviet literature for children is discussed.
A I Safuanova
doaj  

DISCURSIVE REPRESENTATION OF CHARACTERS IN DRAMATIC TEXTS

Мова: кодифікація, компетенція, комунікація, 2021
Вступ. Проблема структурування драматичного тексту, функцій списку дійових осіб у композиційній та семантичній організації п’єси є важливою для інтерпретації твору драматургії. Проникнення в глибинні смислові та текстові зв’язки між аналізованим структурним компонентом та самим текстом уможливлює глибше розуміння естетичного задуму як читачів, так і ...
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Multi-Scale Integrated Analysis of Societal and Ecosystem Metabolism (MUSIASEM): An Outline of Rationale and Theory [PDF]

This paper presents an outline of rationale and theory of the MuSIASEM scheme (Multi-Scale Integrated Analysis of Societal and Ecosystem Metabolism).
Jesus Ramos-Martín, Kozo Mayumi, Mario Giampietro   +2 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Komično v umetnosti za otroke in mlade: kako 93 otroci in mladi dojemajo prvine humorja in se nanje odzivajo

Amfiteater
Komedija in elementi komičnega v umetnosti za otroke in mlade lahko segajo od šaljivega humorja do prefinjene duhovitosti, lahko so namenjeni zgolj zabavi, lahko pa služijo tudi kot način, kako mlajšemu občinstvu posredovati pomembna sporočila, in ga ...
Martina Peštaj, Benjamin Zajc
doaj   +1 more source

Phantom Sensations: What's a Brain to Do? A Critical Review of the Re-mapping Hypothesis [PDF]

, 2018
I will review the most widely held account of phantom sensations; the “re-mapping hypothesis.” According to the re-mapping hypothesis, amputation is followed by significant neural reorganization that, over time, restores the alignment between the brain’s
DeFranco, Daniel
core  

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

Igrske akcije v novomedijskih umetniških delih

Amfiteater
Članek izhaja iz teorije video iger Alexandra R. Gallowaya. Gre za analizo medija, utemeljenega v akcijah, in njegovih specifik. Igrske akcije sistema igre izvajata upravljavec in stroj, odvijajo pa se tako v diegetskem kot nediegetskem prostoru igre. S
Narvika Bovcon
doaj   +1 more source