Results 71 to 80 of about 3,503,740 (331)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Compact Drawings of 1-Planar Graphs with Right-Angle Crossings and Few Bends

, 2018
We study the following classes of beyond-planar graphs: 1-planar, IC-planar, and NIC-planar graphs. These are the graphs that admit a 1-planar, IC-planar, and NIC-planar drawing, respectively.
C Bachmaier, D Harel, FJ Brandenburg, G Liotta, G Ringel, H Fraysseix de, H Purchase, JE Hopcroft, M Chrobak, MA Bekos, P Eades, SG Kobourov, W Didimo, W Huang   +13 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Strict Confluent Drawing [PDF]

, 2013
20 pages, 14 figures, Extended version of a paper to appear at Graph Drawing ...
Eppstein, D., Holten, D., Löffler, M., Nöllenburg, M., Speckmann, B., Verbeek, K.   +5 more
openaire   +10 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Drawing cone spherical metrics via Strebel differentials

, 2018
Cone spherical metrics are conformal metrics with constant curvature one and finitely many conical singularities on compact Riemann surfaces. By using Strebel differentials as a bridge, we construct a new class of cone spherical metrics on compact ...
Cheng, Yiran, Li, Bo, Song, Jijian, Xu, Bin   +3 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Redistricting: Drawing the Line

, 2017
We develop methods to evaluate whether a political districting accurately represents the will of the people. To explore and showcase our ideas, we concentrate on the congressional districts for the U.S. House of representatives and use the state of North
Bangia, Sachet, Graves, Christy Vaughn, Herschlag, Gregory, Kang, Han Sung, Luo, Justin, Mattingly, Jonathan C., Ravier, Robert   +6 more
core   +1 more source

Deep drawing simulation of Tailored Blanks [PDF]

, 1998
Tailored blanks are increasingly used in the automotive industry. A tailored blank consists of different metal parts, which are joined by a welding process. These metal parts usually have different material properties.
Berg, A. van den, Meinders, V.T., Stokman, B.   +2 more
core   +1 more source