Results 41 to 50 of about 2,631,684 (301)
Practical Laboratory Medicine, 2020 Background: Decreased galactocerebrosidase (GALC) enzyme activity is causative for Krabbe disease, a lysosomal storage disorder with devastating neurodegenerative consequences. Quantitative fluorimetric assays for GALC activity in isolated blood and skin
Anirudh J. Ullal +11 more
doaj +1 more source
Egyptian Journal of Medical Human Genetics, 2020 Background Phenylketonuria (PKU), inborn error of metabolism, results from phenylalanine hydroxylase deficiency. PKU leads to neurological manifestations, intellectual disability, and mental disorders.
Amr S. Gouda, Walaa S. Nazim
doaj +1 more source
Investigation of Dried Blood Spot Cards for Fatty Acid Analysis Using Porcine Blood
Veterinary Medicine International, 2021 Fatty acids, especially omega-3 and omega-6 fatty acids, are important for reproductive and cardiovascular health in animals. While monitoring fatty acids is traditionally conducted using frozen blood fractions such as serum and plasma, advancements in ...
Jordan Wood +7 more
doaj +1 more source
Analysis of Lyso-Globotriaosylsphingosine in Dried Blood Spots [PDF]
Annals of Laboratory Medicine, 2013 Recently, lyso-globotriaosylsphingosine (lyso-Gb3) was found to be elevated in plasma of treatment naive male patients and some female patients with Fabry Disease (FD). This study tested whether lyso-Gb3 could be analyzed in dried blood spots (DBS) from filter cards and whether concentrations are elevated in newborn infants with FD.
Johnson, Britt +9 more
openaire +2 more sources
Influence of haematocrit level on the kinetics of blood spreading on thin porous medium during dried blood spot sampling [poster] [PDF]
, 2014 Influence of haematocrit level on the kinetics of blood spreading on thin porous medium during dried blood spot sampling ...
Diganta Das (1254000) +3 more
core +6 more sources
mSphere, 2021 Dried blood spot (DBS) collection provides an easy, practical, and acceptable alternative to venous blood collection, especially for community-based studies, provided that results from DBS are accurate.
Christine Prosperi +23 more
doaj +1 more source
Dried blood spot analysis; facing new challenges
Journal of Applied Bioanalysis, 2015 Over the last decade, DBS analysis has gained popularity for TDM because it’s a patient friendly sampling proce- dure [1-4]. Additional advantages are prolonged sample stability, lower risk of infections and transportation at ambient temperature [1-3,5].
Koster, Remco A +2 more
openaire +2 more sources
The use of freeze-dried blood samples affects the results of a dried blood spot analysis
Clinical Biochemistry, 2022 Dried blood spot (DBS) microsampling has several advantages over venous blood sampling. In a clinical validation study of tacrolimus microsampling it was noted that tacrolimus DBS concentrations ([Tac]DBS) were systematically higher than tacrolimus whole-blood concentrations ([Tac]WB).
Francke, Marith I. +4 more
openaire +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source