Results 71 to 80 of about 113,240 (348)

Using dried blood spot on HemoTypeSC™, a new frontier for newborn screening for sickle cell disease in Nigeria

Frontiers in Genetics, 2022
Background: HemoTypeSC is a rapid, point-of-care testing (POCT) device for sickle cell disease (SCD) that traditionally uses the capillary blood from heel stick collected at the point of testing, a procedure that makes mass screening cumbersome and less ...
Chinwendu O. Okeke, R. Chianumba, H. Isa, S. Asala, O. Nnodu   +4 more
semanticscholar   +1 more source

Evaluation of an HIV recent infection testing algorithm with serological assays among men who have sex with men in Mexico

Journal of Infection and Public Health, 2020
Background: Human immunodeficiency virus (HIV) incidence should be calculated in cross-sectional studies using recent infection testing algorithms (RITA) that consider clinical variables and serological test results such as enzyme-linked immunosorbent ...
Eli F. Karatzas-Delgado, Verónica Ruiz-González, Santa García-Cisneros, María L. Olamendi-Portugal, Antonia Herrera-Ortiz, Hugo López-Gatell, Andrea González-Rodríguez, Miguel A. Sánchez-Alemán   +7 more
doaj   +1 more source

HCV microelimination in harm reduction centres has benefits beyond HCV cure but is hampered by high reinfection rates

JHEP Reports, 2022
Background & Aims: Significant scale-up of treatment among people who inject drugs (PWID) is crucial to achieve WHO HCV elimination targets. We explored the impact of on-site HCV diagnosis and treatment on PWID in an externalised hepatology clinic at
Sabela Lens, Anna Miralpeix, Mont Gálvez, Elisa Martró, Noemi González, Sergio Rodríguez-Tajes, Zoe Mariño, Verónica Saludes, Juliana Reyes-Urueña, Xavier Majó, Joan Colom, Xavier Forns   +11 more
doaj   +1 more source

The prevalence of hepatitis C virus among people of South Asian origin in Glasgow: results from a community based survey and laboratory surveillance [PDF]

, 2013
Background South Asians often present late with HCV or HBV related liver disease which could have been avoided with early diagnosis and subsequent treatment; however the prevalence of HCV/HBV among South Asians in Glasgow is not known.
Ahmed, S., Anderson, Eleanor, Banday, Shabir, Cameron, Sheila, Foster, Graham R., Fox, Ray, Goldberg, David, Hutchinson, Sharon J., McLeod, Allan, McTaggart, Christine, Mills, Peter R., O'Leary, Maureen C., Sarwar, Mohammed, Schofield, Joe, Weir, Amanda   +14 more
core   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Verification of dried blood spot as a sample type for HIV viral load and early infant diagnosis on Hologic Panther in Zambia

BMC Research Notes, 2023
Objective Zambia has embarked on improving the diagnostic capacity by setting up high throughput and accurate machines in the testing process and introduction of dried blood spot (DBS) as a sample type.
Precious Simushi, Mukoshya Nchima Kalunga, Tuku Mwakyoma, Mulenga Mwewa, Lweendo Muchaili, Nchimunya Hazeemba, Chileshe Mulenga, Patience Mwewa, Kaseya O. R. Chiyenu, John Kachimba, Powell Choonga, Aaron Shibemba, Benison M. Hamooya, Mowa Zambwe, Peter J. Chipimo, Lackson Kasonka   +15 more
doaj   +1 more source

Integrated Serologic Surveillance of Population Immunity and Disease Transmission. [PDF]

, 2018
Antibodies are unique among biomarkers in their ability to identify persons with protective immunity to vaccine-preventable diseases and to measure past exposure to diverse pathogens. Most infectious disease surveillance maintains a single-disease focus,
Arnold, Benjamin F, Lammie, Patrick J, Priest, Jeffrey W, Scobie, Heather M   +3 more
core   +1 more source

Treatment algorithm for infants diagnosed with spinal muscular atrophy through newborn screening [PDF]

, 2018
Spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by the degeneration of alpha motor neurons in the spinal cord, leading to muscular atrophy.
Connolly, Anne, Crawford, Thomas O, Darras, Basil, Day, John, Finkel, Richard, Glascock, Jacqueline, Haidet-Phillips, Amanda, Howell, R. Rodney, Jarecki, Jill, Ker, Douglas, Klinger, Katherine, Kuntz, Nancy, Prior, Thomas, Sampson, Jacinda, Shieh, Perry B   +14 more
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source