Results 81 to 90 of about 113,240 (348)

Early infant diagnosis: A new tool of HIV diagnosis in children

Indian Journal of Community Medicine, 2011
Background: Standard assay has limited utility in diagnosing HIV reactivity among infants till the age of 18 months by which time, many HIV-infected infants expire.
Kamlesh Kumar Jain, Raj Kumar Mahajan, Manoj Shevkani, Pradeep Kumar   +3 more
doaj   +1 more source

Strategies for the treatment of Hepatitis C in an era of interferon-free therapies: what public health outcomes do we value most? [PDF]

, 2014
Objective: The expense of new therapies for HCV infection may force health systems to prioritise the treatment of certain patient groups over others.
Dillon, John, Goldberg, David, Hutchinson, Sharon J, Innes, Hamish   +3 more
core   +1 more source

A stepped wedge cluster randomized control trial of dried blood spot testing to improve the uptake of hepatitis C antibody testing within UK prisons

European Journal of Public Health, 2014
Background: The prevalence of hepatitis C (HCV) is elevated within prison populations, yet diagnosis in prisons remains low. Dried blood spot testing (DBST) is a simple procedure for the detection of HCV antibodies; its impact on testing in the prison ...
N. Craine, R. Whitaker, S. Perrett, L. Zou, M. Hickman, M. Lyons   +5 more
semanticscholar   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Dried blood spots are a valid alternative to venipuncture for COVID-19 antibody testing

JIM - Journal of Immunological Methods, 2022
Background Serologic analysis is an important tool towards assessing the humoral response to COVID-19 infection and vaccination. Numerous serologic tests and platforms are currently available to support this line of testing.
M. Sims, R. Podolsky, K. Childers, B. Higgins, J. Trueman, R. Homayouni, Daniel R Voss, Natalie Berkiw-Scenna, Hans Keil, Richard H. Kennedy, G. Maine   +10 more
semanticscholar   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Performance of Immunoglobulin G Serology on Finger Prick Capillary Dried Blood Spot Samples to Detect a SARS-CoV-2 Antibody Response

Microbiology Spectrum, 2022
We investigate the diagnostic accuracy and predictive value of finger prick capillary dried blood spot (DBS) samples tested by a quantitative multiplex anti-immunoglobulin G (IgG) assay to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV ...
Aidan M. Nikiforuk, Brynn McMillan, Sofia R. Bartlett, Ana Citlali Márquez, Tamara Pidduck, Jesse Kustra, David M. Goldfarb, Vilte Barakauskas, Graham Sinclair, David M. Patrick, Manish Sadarangani, Gina S. Ogilvie, Mel Krajden, Muhammad Morshed, Inna Sekirov, Agatha N. Jassem   +15 more
doaj   +1 more source

Emergence of Novel Psychoactive Substance injecting associated with rapid rise in the population prevalence of hepatitis C virus [PDF]

, 2019
Background: Novel Psychoactive Substance (NPS) use has increased in recent years and generated significant concern within public health. People who inject drugs (PWID) are at increased risk of blood borne viruses, in particular Hepatitis C virus (HCV ...
Goldberg, David J., Hutchinson, Sharon J., McAuley, Andrew, Munro, Alison, Taylor, Avril, Yeung, Alan   +5 more
core   +3 more sources

Congenital Cytomegalovirus Infection: A Narrative Review of the Issues in Screening and Management From a Panel of European Experts. [PDF]

, 2020
Maternal primary and non-primary cytomegalovirus (CMV) infection during pregnancy can result in in utero transmission to the developing fetus. Congenital CMV (cCMV) can result in significant morbidity, mortality or long-term sequelae, including ...
Blázquez-Gamero, D, Delforge, M-L, Foulon, I, Lazzarotto, T, Leruez-Ville, M, Luck, S, Modrow, S   +6 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source