Results 181 to 190 of about 879,918 (311)

New Insights into Heavy Metal Sequestration Through Metal‐Phenolic Network‐Confined Nano‐HFO: Overlooking Iron Utilization and Modulating Electron Density

Advanced Science, EarlyView.
Iron‐based nanocomposites are widely used for trace heavy metal removal, but the low utilization of HFO nanoparticles remains a challenge. Here, a metal‐phenolic network (MPN) strategy is proposed to confine nano‐HFO within polystyrene beads, creating a negative electrostatic field and optimizing electron density at oxygen sites. This approach enhances
Manyu Zhang, Xiaolin Du, Zhanqi Liu, Yujia Yang, Shuo Wang, Ningyi Chen, Yulin Wang, Yaran Song, Keju Sun, Qingrui Zhang   +9 more
wiley   +1 more source

Investigation and risk assessment of fluoride concentration in drinking water, soil and food products in Hamedan rural areas. [PDF]

Sci Rep
Asgari G, Salari M, Seidmohammadi A, Akbari-Adergani B, Mahvi AH, Kamari N, Rastegar KE, Faraji H.   +7 more
europepmc   +1 more source

Plasmon Enhanced Universal SERS Detection of Hierarchical Plastics by 3D Plasmonic Funnel Metastructure

Advanced Science, EarlyView.
A 3D self‐assembled plasmonic nanostructure for ultrasensitive SERS detection of hierarchical micro‐nano plastic pollutants ranging from 30 nm to microns by rationally integrating high density of both surface and volumetric hot spots into one structure, enabled by V‐shaped close‐packed bi‐metallic nanoparticles with massive nanovoids across transverse ...
Weixi Lu, Jian Luo, Yuyang Zhuang, Jie Liang, Min Xiong, Hui Liu, Lin Zhou   +6 more
wiley   +1 more source

The predictive value of participant subgroups in a temporary alcohol abstinence challenge: compliance with abstinence and changes in drinking behaviour. [PDF]

Alcohol Alcohol
Kools N, Rozema AD, van de Mheen D, Bovens RHLM, Mathijssen JJP.   +4 more
europepmc   +1 more source

PRMT5 Inhibitor Synergizes with Chemotherapy to Induce Resembling Mismatch Repair Deficiency and Enhance Anti‐TIGIT Therapy in Microsatellite‐Stable Colorectal Cancer

Advanced Science, EarlyView.
Microsatellite‐stable (MSS) colorectal cancer (CRC) resists immunotherapy. PRMT5 inhibition enhances CPT‐11 sensitivity, inducing a PMS2‐deficient‐like state and cytosolic dsDNA release, which activates the cGAS‐STING pathway to promote anti‐tumor immunity. However, this combination therapy upregulates TIGIT expression on CD8+ T cells, and the addition
Jiang Zhu, Shenao Fu, Xi Zou, Hanjiang Zeng, Guangzu Cui, Yinghui Peng, Diya Tang, Fan Zhang, Hong Shen, Shan Zeng, Ying Han   +10 more
wiley   +1 more source

Engineered Genetic Circuits Activated by Bezafibrate Improve ESC‐Based TAA Cancer Vaccine Efficacy and PD‐L1 Nanobody Therapy

Advanced Science, EarlyView.
Synthetic gene circuits regulated by bezafibrate are developed to express tumor antigens and PD‐L1 nanobody (PD‐L1nb), enhancing cancer immunotherapy. Delivered via HEK293T cells, ESCs, or directly injected the plasmids containing the circuit into the tumor, the circuits reduce tumor growth, boost CD8+ T cells, and minimize T cell exhaustion.
Meiling Jin, Shuzhen Liu, Mingshuo Zhan, Jian‐Dong Huang   +3 more
wiley   +1 more source

Health risk assessment of toxic elements in Kashan drinking water reservoirs using Monte Carlo simulation and sensitivity analysis. [PDF]

Sci Rep
Nemati B, Fallahizadeh S, Mostafaei G, Miranzadeh MB.   +3 more
europepmc   +1 more source

Dual Role of CRABP2 in Colorectal Cancer: Oncogenesis via Nuclear RB1 and Cytoplasmic AFG3L2/SLC25A39 Axis, While Limiting Liver Metastasis through Cytoplasmic AFG3L2/PINK1/Parkin‐Mediated Mitophagy

Advanced Science, EarlyView.
CRABP2 plays a dual role in colorectal cancer: it promotes proliferation and suppresses apoptosis through the nuclear CRABP2/RB1 axis and the cytoplasmic AFG3L2/SLC25A39 axis. Meanwhile, it inhibits colorectal liver metastasis via AFG3L2/PINK1/Parkin‐mediated mitophagy.
Chuanxin Tian, Sheng Yang, Chuan Zhang, Renzhong Zhu, Chen Chen, Xiaowei Wang, Dongsheng Zhang, Qingyang Sun, Hengjie Xu, Hongxu Nie, Yue Zhang, Dongjian Ji, Junwei Tang, Kangpeng Jin, Yueming Sun   +14 more
wiley   +1 more source

Predictors of alcohol use disorder risk in young adults: Direct and indirect psychological paths through binge drinking. [PDF]

PLoS One
Mauduy M, Maurage P, Mauny N, Pitel AL, Beaunieux H, Mange J.   +5 more
europepmc   +1 more source

Efficient Generation of Megakaryocyte Progenitors and Platelets From HSPCs via JAK2/STAT3 Signaling

Advanced Science, EarlyView.
This research presents a novel strategy employing the VGM cocktail, which combines HES7 overexpression with HDAC inhibitor and GABA, to enhance platelet production from hematopoietic stem and progenitor cells by promoting megakaryocyte progenitor (MkP) generation.
Huicong Liu, Lingna Wang, Jiaqing Liu, Haitao Yuan, Kaiqing Zhang, Yun Qiu, Fangfang Zhu   +6 more
wiley   +1 more source