Results 101 to 110 of about 1,122,007 (300)

(2008) Wellhead Protection Program - Lary Lane, Gilman, and Stadium Wells in the Town of Exeter, NH [PDF]

, 2008
A Wellhead Protection Program (WHPP) identifies existing and potential sources of contamination to public water supply wells. The purpose of a WHPP is to prevent contamination of groundwater used for drinking water, recognizing the best way to maintain ...
Wellhead Protection Program
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DADA Enhances CD8+ T Cell Stemness to Improve Anti‐Tumor Immunity and Immunotherapy Efficacy

Advanced Science, EarlyView.
Diisopropylamine dichloroacetate (DADA) enhances CD8+ T cell stemness by improving OXPHOS and mitochondrial fitness in a PDK1‐depenpendent manner. This metabolic shift strengthens CD8+ T cell anti‐tumor immunity, improves responses to PD‐1 blockade, and endows CAR‐T cells with prolonged persistence and resistance to terminal exhaustion, highlighting a ...
Mingyue Bi, Fei Li, Heng Jiang, Lingling Gu, Mengjie Sun, Kunyu Lu, Pianpian Liu, Ruyue Xie, Wenqiang Ma, Meijuan Zheng, Xianwei Wang, Xuefu Wang, Jingjing Cong   +12 more
wiley   +1 more source

Changes of Physicochemical Characteristics of Microplastics During Water Disinfection Processes: A Review

能源环境保护
Microplastic pollution in aquatic environments has drawn widespread attention. In addition to the toxicity and ecological risks, microplastics can act as carriers of various pollutants. In water disinfection processes, disinfectants can induce changes in
Shuo ZHANG, Xian ZHANG, Hang LIU, Chenhao TIAN, Miao WANG, Guoqi SHI, Chao LIU   +6 more
doaj   +1 more source

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

Urine metabolomic characteristics of people exposed to hexavalent chromium in drinking water

Ecotoxicology and Environmental Safety
This study investigated the toxicological mechanisms of hexavalent chromium (Cr(VI)) exposure on human health by analyzing the urinary metabolomics of residents exposed to Cr(VI) through drinking water.
Tao Yanan, Hu Miaomiao, Xia Yunting, Peng Fangda, Xiong Chuanlong, Ding Chunguang   +5 more
doaj   +1 more source

Performance of Broiler Chickens Offered Drinking Water Contained Water Extracted Beluntas (Pluchea Indica L.) Leaf and Sugar Cane [PDF]

, 2012
Our previous study showed that the addition of water extracted beluntas leaf into drinking water could be used as an anti-stress and improved performance of broiler chicken. However, the addition was only up to 10% of drinking water.
Kaniadewi, R. (R), Sudarman, A. (A), Sumiati, S. (Sumiati)   +2 more
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Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Organophosphate esters in reservoir water from a metropolitan city in the Guangdong-Hong Kong-Macao Greater Bay Area, China, and their ecological risk

Emerging Contaminants
Organophosphate esters (OPEs) are emerging flame retardants widely used in products such as furniture, electronic equipment, construction, and plastics. It has been demonstrated that OPEs are harmful to humans and aquatic organisms, thus posing a threat ...
Yi Huang, Yiming Ge, Chenglin Li, Linshen Xie, Xiujuan Qi, Pu Ye, Xixiang Guo, Chen Deng, Rong Hu, Jinling Wang, Yihong Liu, Bei Wang, Tingting Zhu, Shaoyou Lu   +13 more
doaj   +1 more source

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

DRINKING WATER FLUORIDE CONCENTRATION AND ITS RELATIONSHIP WITH DMFT INDEX IN MIANEH CITY, IRAN [PDF]

The purpose of this research was to determine the fluoride concentration in drinking water of Mianeh city in the province of East Azerbaijan, Iran. This crosssectional research was carried out on all 14 groundwater sources of drinking water in 2008.
حیدری, محسن, فضل زاده دویل, مهدی, مظلومی, سجاد, هیبتی, بهزاد   +3 more
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