Results 111 to 120 of about 5,874,199 (333)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Bars do drive spiral density waves

, 2010
Recently, Buta etal. (2009) examined the question "Do Bars Drive Spiral Density Waves?", an idea supported by theoretical studies and also from a preliminary observational analysis Block etal (2004).
Athanassoula, Bertin, Binney, Block, Bosma, Buta, Buta, Buta, Buta, Elmegreen, Eskridge, Knapen, Lindblad, Masset, Rautiainen, Salo, Salo, Sellwood, Sellwood, Sellwood, Sheth, Sheth, Skrutskie, Speltincx, Toomre   +24 more
core   +1 more source

Development of a confinable gene drive system in the human disease vector Aedes aegypti

bioRxiv, 2019
Aedes aegypti, the principal mosquito vector for many arboviruses that causes yellow fever, dengue, Zika, and chikungunya, increasingly infects millions of people every year. With an escalating burden of infections and the relative failure of traditional
Ming Li, Ting Yang, Nikolay P. Kandul, Michelle Bui, Stephanie Gamez, Robyn R. Raban, Jared B. Bennett, H. Sánchez C., G. Lanzaro, Hanno Schmidt, Yoosook Lee, John M. Marshall, O. Akbari   +12 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Considerations on destruction and creation based on the drive to seize [PDF]

Psicologia: Teoria e Pesquisa
This study presents a perspective on the psychic work of destruction and creation as an expression of the drive to seize, reassessing the theme. Methodologically, it takes up the Freudian hypothesis in which this drive is involved in the organization of ...
Antônio Trevisan, Márcia Cristina Maesso, Jean-Michel Vivès   +2 more
doaj   +1 more source

Child of Steel [PDF]

, 1983
[Excerpt] After several months of thinking about what is happening to the working class, particularly the steel industry and the whole system of labor, this poem came to me. I drive by Homestead Mill every morning to get to my job and to get home I drive
Massaro, Anthony
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source