Results 131 to 140 of about 2,007,083 (298)

Michi‑Drive (U‑Drive) as the Base Drive of Life

This work introduces the Michi‑Drive (U‑Drive), a structural and implementation‑agnosticinformation‑gradient model that defines the fundamental dynamical force driving livingsystems toward the unknown. It formalizes the known/unknown distinction, the BaseDrive,and the algorithmic structure of exploration without relying on psychological constructssuch ...
openaire   +1 more source

Leaf metabolites drive the functional composition of the phyllosphere microbiome in tea plants

Beverage Plant Research
The phyllosphere microbiome is a complex and dynamic community that influences plant growth and health. However, the mechanisms underlying the functional assembly of the phyllosphere microbiome driven by host metabolites remain largely elusive.
Xiangfeng Tan, Qianhong Pan, Zheng Zhang, Dedong Kong, Ping Xu   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

NUEVE NOTAS SOBRE EL CONCEPTO DE PULSIÓN EN LA OBRA DE J. LACAN

Affectio Societatis, 2015
This paper is intended as an introductory review of the concept of drive in Lacan's work. This notion is central to psychoanalytic theory and clinic; therefore, it is always convenient to recall the novelties introduced by Lacan on this topic.
Bruno Bonoris
doaj  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Load of Cutting Units Drives of Mining Equipment. Part 1. Methodological Approaches to Monitoring of Technical Condition of Shearer Cutting Unit by Parameters of its Drive Load

Механика машин, механизмов и материалов, 2019
A mathematical model of the load of the shearer drive of the drum type cutting unit is introduced. It takes into account the speed of its movement, the angular speed of rotation of the cutting unit, the taper angle of the cutting part and the number of ...
Alexander S. Romanovich, Ivan A. Kanaplianik   +1 more
doaj