Results 111 to 120 of about 309,624 (329)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
The comparison of vibro-acoustic impact of chainsaws with electric and combustion drives
MATEC Web of Conferences, 2018 Chainsaws generate high level vibrations and noise during work. No matter what type of the drive (electric, combustion) they exceed the per-missible levels defined for a standard eight-hour working day.
Rukat Wojciech +3 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Jixie chuandong, 2008 In order to study the effect of new sprocket for timing roller chain drive,dynamic simulations are carried out respectively about four timing roller chain drive systems in which four sprockets are exploited respectively such as ISO-606 sprocket,JIS-B1802
顾仁涛, 王勇
doaj
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Developing Customer Responsive Supply Chain Strategy: An Empirical Investigation of the Relationship between Market Segmentation and Supply Chain Strategy [PDF]
, 2008 The concept of the ‘supply chain’, rather than a set of independent functions, has been around for more than 25 years. Despite its theoretical longevity, many organisations still struggle to make the supply chain a reality.
Godsell, Janet
core
Design and Study of Pre-stretching and Disassembling Device for Double-row Chain
Jixie chuandong, 2019 Aiming at the pre-stretching and disassembling link in the manufacturing process of double-row chain, a new type of pre-stretching and disassembling device for double-row chain is designed.
Wang Shukun +4 more
doaj
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
STUDY ON SIMULATION OF CHAIN DRIVE’DYNAMIC BEHAVIOR BASED ON RECURDYN
Jixie qiangdu, 2017 Chain drive is a convenient mechanical transmission for use,which has such characteristics as compact structure and high reliability.Chain is a flexible body.In the course of transmission,the polygon effect and the meshing impact are the fundamental ...
TAO DongBo +3 more
doaj