Results 101 to 110 of about 177,671 (299)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Effect of Pile Bending Stiffness on Static Lateral Behavior of a Short Monopile in Dry Sand

International Journal of Coastal and Offshore Engineering, 2017
Monopiles are common foundations for offshore structures such as wind turbines and they are commonly used as fender piles in port structures. In such structures, especially in OWTs, the ratio of pile length to diameter (L/D) is small which makes the pile
Saeed Darvishi Alamouti, Mohammad Reza Bahaari, Majid Moradi   +2 more
doaj  

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Evaluation Of Bearing Capacity For Model Piles Driven In Sandy Soil

Journal of Engineering and Sustainable Development, 2014
This study represents an effort to study the effect of driven pile type and relative density of the sand on the evaluation of bearing capacity of pile under two different types of loading, compression and tension (uplift) loads.
Saad Farhan Ibrahim, Hasanain F.Hasan, Amjad I. Fadhil   +2 more
doaj  

Numerical analysis of negative skin friction on piles in soft clay

HBRC Journal, 2013
Negative skin friction is considered one of the problems in the design of piled foundations in soft soil. The negative skin friction induces an additional compressive force on the pile called the dragload as well as, an additional pile movement called ...
Yasser M. El-Mossallamy, Ashraf M. Hefny, Magdy A. Demerdash, Mohamed S. Morsy   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Impact-Driven Penetration of Multi-Strength Fiber Concrete Pyramid-Prismatic Piles

Buildings
The article focuses on studying the impact-driven penetration of multi-strength fibroconcrete pyramid-prismatic piles. The research object includes multi-strength pyramid-prismatic piles with varying types of reinforcement and different levels of ...
Isabai Bekbasarov, Nurzhan Shanshabayev, Yerlan Atenov   +2 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Avalanche dynamics, surface roughening and self-organized criticality - experiments on a 3 dimensional pile of rice

, 2003
We present a two-dimensional system which exhibits features of self-organized criticality. The avalanches which occur on the surface of a pile of rice are found to exhibit finite size scaling in their probability distribution. The critical exponents are $
A. Malthe-Sørenssen, A. Myllys, A. Sornette, C. M. Aegerter, C.M. Aegerter, C.M. Aegerter, D. Stassinopoulos, E. Altshuler, E. Ben-Jacob, E.R. Nowak, G. Szabo, H. Flyvbjerg, H.M. Jaeger, J. Bascompte, J. Kertész, J. Maunuksela, J. Schmittbuhl, J.A. Scheinmann, J.G. Amar, J.M. Carlson, J.M. Lopez, K. Behnia, K. Behnia, M. Alava, M. Alava, M. Kardar, M. Paczuski, M. Paczuski, M. Siegert, M.A. Rubio, O. Peters, O. Peters, P. Bak, P. Bak, P. Bak, P. Bak, R. Günther, R. J. Wijngaarden, R. Surdeanu, R.J. Zieve, S. Field, S. He, S. Matsuura, S.A. Kaufmann, S.R. Nagel, T. Vicsek, V. Frette, V.K. Horváth   +47 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source