Results 91 to 100 of about 2,232,082 (389)

Mechanical and numerical behavior of water jet-driven under-reamed concrete piles [PDF]

, 2023
Cesar Alberto Ruver, Giovani Jordi Bruschi   +1 more
openalex   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pile-Soil Interaction in Unsaturated Soil Conditions [PDF]

, 2014
The degree of saturation has been proven to significantly affect geotechnical engineering designs for foundations. The changes in water content will influence the way the soil behaves, including its strength and stiffness parameters.
Hamilton, Megan
core   +2 more sources

On the dynamics of planetesimals embedded in turbulent protoplanetary discs with dead zones [PDF]

, 2011
(abridged) Accretion in protoplanetary discs is thought to be driven by [...] turbulence via the magnetorotational instability (MRI). Recent work has shown that a planetesimal swarm embedded in a fully turbulent disc is subject to strong excitation of ...
Alibert, Armitage, Asphaug, Balbus, Baruteau, Benz, Blaes, Brandenburg, Brandenburg, Brauer, Bridges, Chiang, Courvoisier, Cuzzi, Davis, Flaig, Fleming, Fleming, Flock, Fromang, Gammie, Gardiner, Garmire, Glassgold, Goldreich, Gradie, Gressel, Gressel, Haisch, Hanasz, Hawley, Hawley, Hayashi, Heinemann, Heinemann, Hirose, Ida, Ida, Igea, Ilgner, Ilgner, Ilgner, Johansen, Johansen, Johansen, Johansen, Johnson, Kenyon, Kokubo, Kortenkamp, Korycansky, Latter, Latter, Lin, Miller, Miyoshi, Mothé-Diniz, Neal J. Turner, Nelson, Nelson, Nelson, Oishi, Oliver Gressel, O’Brien, Papaloizou, Pessah, Pollack, Regev, Rheinhardt, Richard P. Nelson, Richardson, Rüdiger, Sano, Shi, Sicilia-Aguilar, Stewart, Stone, Stone, Turner, Turner, Turner, Umebayashi, Umebayashi, Umebayashi, Wardle, Weidenschilling, Weidenschilling, Weidenschilling, Wetherill, Yang, Youdin, Ziegler, Ziegler, Zsom   +93 more
core   +2 more sources

Equations Used to Calculate Vertical Bearing Capacity of Driven Piles with Shaft Broadenings

, 2020
In a pile foundation setting practice driven piles with an unconventional (variable) longitudinal shape of surface are widely used. Such piles are made with various slopes of the side faces, may have different types of broadenings, thickenings, etc.
Y. Atenov, Isabai Bekbasarov
semanticscholar   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Dilatancy in slow granular flows [PDF]

, 2016
When walking on wet sand, each footstep leaves behind a temporarily dry impression. This counterintuitive observation is the most common illustration of the Reynolds principle of dilatancy: that is, a granular packing tends to expand as it is deformed,
Kabla, Alexandre J, Senden, Timothy
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source