Results 191 to 200 of about 476,852 (262)

Diverse genomic and transcriptomic heterogeneity in EGFR-mutant lung adenocarcinoma between exon 19 del and exon 21 L858R. [PDF]

Cell Commun Signal
Yang Y, Qiao S, Sun D, Zhang Z, Zhao Y, Zhan J, Huang Y, Zhao H, Yang Y, Wu K, Zhou X, Zhang L, Long H, Yang H, Wang J, Wang X, Wen Z, Zhang L, Zhang L, Fang W, Zhao X, Zhang Y.   +21 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Lane departure on combined curves: driver heterogeneity, centrifugal risk, and crash prevention. [PDF]

Sci Rep
Wang X, Zhang Y, Li Y, Yi X, Wang X, Hao G.   +5 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

MODCAN: driver gene identification based on multi-omics features and differential co-association networks for tumor subtypes. [PDF]

BMC Bioinformatics
Li P, Xiao G, Wang H, Xu C, Zhang Y.
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Evaluation of the level of responsibility in pedestrian crashes using machine learning algorithms. [PDF]

Sci Rep
Moreno-Sanfélix A, Gragera-Peña FC, Jaramillo-Morán MA.   +2 more
europepmc   +1 more source

The efficacy and predictive factors of first-line immune checkpoint inhibitors for advanced non-small cell lung cancer with driver or non-driver gene alterations: a retrospective cohort study. [PDF]

J Thorac Dis
He Q, Guo XB, Chen YR, Gao XX, Zhao J, Zhong W, Chen MJ, Xu Y, Wang MZ.   +8 more
europepmc   +1 more source

Electric vehicle charging station recommendation system based on graph neural network and context-aware refinement. [PDF]

Sci Rep
Seo D, Moon J, Kwon HY.
europepmc   +1 more source