Results 171 to 180 of about 1,796,768 (309)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Correlates of unsafe driving in non-professional drivers: insights from a data-driven modeling approach. [PDF]

J Egypt Public Health Assoc
Abdolrazaghi A, Mirzahossein H.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Gasoline Prices and Their Relationship to Drunk-Driving Crashes [PDF]

his study investigates the relationship between changing gasoline prices and drunk-driving crashes. Specifically, we examine the effects of gasoline prices on drunk-driving crashes in Mississippi by age, gender, and race from 2004Ð2008, a period ...
Paul Gilbert, Xuan Zhou, Arthur Cosby, Guangqing Chi, Timothy McClure, Angela Robertson, Li Zhang, David Levinson   +7 more
core  

Visual field and driving performance of individuals with inherited retinal disorders: a scoping review. [PDF]

BMJ Open Ophthalmol
Bell XE, Grigg JR, Fraser CL, Cornish EE.   +3 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Synopsis of the final report of the Kansas Governor's Committee on Drinking and Driving [1982]

, 1982
Submitted to Governor John Carlin, December 13, 1982.Kansas Governor's Committee on Drinking and Driving -- Synopsis Of The Final Report Of The Kansas Governor's Committee On Drinking And Driving -- Background -- Review of the Recommendations by Category
Governor's Committee of Drinking and Driving
core  

HazAPP: Study protocol of a randomized controlled trial to enhance parental instruction of teens' hazard anticipation skill during the learner phase of licensure. [PDF]

Inj Epidemiol
O'Neal EE, Mucciolo E, Rokke-Smith G, Swanson B.   +3 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Insights From Older People With Dementia and Mild Cognitive Impairment on the Management of Driving Cessation by Health Professionals: A Qualitative Study. [PDF]

Australas J Ageing
Spargo C, Laver K, Adey-Wakeling Z, Berndt A, George S.   +4 more
europepmc   +1 more source