Results 91 to 100 of about 1,572,522 (294)

Multimodal Polynomial Fusion for Detecting Driver Distraction

open access: yes, 2018
Distracted driving is deadly, claiming 3,477 lives in the U.S. in 2015 alone. Although there has been a considerable amount of research on modeling the distracted behavior of drivers under various conditions, accurate automatic detection using multiple ...
Black, Alan W   +4 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Evaluating the Effectiveness of a School-Based Intervention on Driving-Related Carbon Emissions Using Real-Time Transportation Data [PDF]

open access: yes, 2019
The development of tools that can measure the efficiency of individual driving behaviors offers unique opportunities to encourage drivers towards more efficient driving behaviors.
Centeno, Diana, Cordero, Eugene
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Comment on ``Dynamic behavior of anisotropic non-equilibrium driving lattice gases''

open access: yes, 2003
In a recent Letter Albano and Saracco study the dynamic critical behavior of some anisotropic driven lattice gases by Monte Carlo (MC) simulations. In this Comment we point out that the Ans\"atze they use to relate the measured scaling exponents with the
Andrea Gambassi   +7 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Melting a granular glass by cooling

open access: yes, 2013
Driven granular systems readily form glassy phases at high particle volume fractions and low driving amplitudes. We use computer simulations of a driven granular glass to evidence a re-entrance melting transition into a fluid state, which, contrary to ...
Heussinger, Claus, Plagge, Jan
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Droplet traffic in microfluidic networks: A simple model for understanding and designing

open access: yes, 2007
We propose a simple model to analyze the traffic of droplets in microfluidic ``dual networks''. Such functional networks which consist of two types of channels, namely those accessible or forbidden to droplets, often display a complex behavior ...
Ajdari, A., Schindler, M.
core   +1 more source

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