Results 121 to 130 of about 1,894,819 (256)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Validating on-the-limit properties of a driving simulator
, 2014 The paper describes a validation model for both subjective and objective comparison of on-the-limit properties of a driving simulator. VTI moving base driving simulator, SIM III, has been used with three different versions of VTI’s vehicle model, for ...
Kharrazi, Sogol +4 more
core
Dynamic Modeling of the 6-UPRU Stewart Platform and Analysis of the Passive Screw Effect
MachinesThe passive screw effect of the UPRU limbs can materially affect the predicted driving forces of a 6-UPRU Stewart platform. To address this issue, this paper presents dynamic modeling and analysis that account for the passive screw influence.
Lingtao Huang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Driving Forces of Inflation in New EU Countries (in English) [PDF]
Driving forces of inflation in the eight new EU member states from Central and Eastern Europe are analyzed using the generalized dynamic-factor model (GDFM) developed by Forni et al. the impact of various macroeconomic variables on inflation is estimated
Emil STAVREV
core
Shuitu baochi yanjiu, 2007 Using the long sequence statistical data of cultivated land of Fuling district and the corresponding social resources and economic resources during the period 1980～2004,the change trend and current status of the cultivated land of Fuling district are ...
HOU Song-ting, CHEN Xiao-yan
doaj
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
, 2011 In recent years, hollow fiber based liquid-liquid-liquid micro-extraction (HF-LLLME) [1] has been widely studied due to its higher enrichment factor, excellent ability of clean-up, and lower consumption of organic solvent.
沈铮, 关亚风, 吴倩, 吴大朋
core