Results 111 to 120 of about 1,894,819 (256)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

All-optical reporting of inhibitory receptor driving force in the nervous system

Nature Communications
Ionic driving forces provide the net electromotive force for ion movement across receptors, channels, and transporters, and are a fundamental property of all cells.
Joshua S. Selfe, Teresa J. S. Steyn, Eran F. Shorer, Richard J. Burman, Kira M. Düsterwald, Ariel Z. Kraitzick, Ahmed S. Abdelfattah, Eric R. Schreiter, Sarah E. Newey, Colin J. Akerman, Joseph V. Raimondo   +10 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Rolling out a new Driving Simulator Concept - Design and Challenges of Wheeled Mobile Driving Simulators

, 2021
Wheeled mobile driving simulators (WMDS) intend to cue the motion of road vehicles by moving a tire-bound, electrically driven, omnidirectional platform.
Albrecht, Torben, Winner, Hermann, Chen, Xing, Roßmeier, Willy, Ottensmeier, Meike, Plaettner, Stefan, Zöller, Chris, Tüschen, Thomas, Prokop, Günther, Lutwitzi, Melina   +9 more
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Mechanisms and Driving Forces of Safety Culture Co-Creation in the Forest Industry

Safety
The forest industry is one of the most dangerous workplaces worldwide, and although safety culture is recognized as important safety antecedent, there is still a theoretical and practical need for understanding how safety culture is co-created in the ...
Alina Linden, Henrik Barth, Pia Ulvenblad, Elin Karlsson, Rom Rwamamara   +4 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Driving Forces of European Landscape Change

, 2021
This master's thesis examines driving forces of landscape change in the Wadden Sea region. The region is a UNESCO World Natural Heritage site and encompasses North Sea coasts of Denmark, Germany and the Netherlands.
MATT, Gordon
core  

Driving offences [PDF]

, 2010
Copyright @ 2010, Taylor & Francis Group. This material is posted on this site with the permission of the publishers.This chapter on driving offences will largely follow the template of earlier chapters except that owing to their vast number, a limited ...
Corbett, C
core   +1 more source