Results 101 to 110 of about 1,894,819 (256)
Forecasting of Future Academic Libraries with Cross Impact Analysis Approach
International Journal of Information Science and Management, 2020 This study uses forecasting approach based on key driving forces and their interactions in order to identify important driving forces affecting the future of academic libraries in Iran.
Soudeh Torabian +3 more
doaj
Reprogramming Mind for Business Success [PDF]
Ovidius University Annals: Economic Sciences Series, 2018 In the context of business, an opportunity for guaranteed success is to reprogram our mind, diffuse disputes, zap away limiting habits and beliefs and step into more positive feelings.
Zamfir Cristina Mihaela
doaj
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Driving Forces behind Snapchat Success
, 2017 This paper tries to explain the driving forces behind Snapchat despite the difficulty in it ...
Vaezi, Reza
core
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Control of a Dynamic Driving Simulator: Time-Variant Motion Cueing Algorithms and Prepositioning [PDF]
, 2006 This thesis mainly addresses the task to provide the driver of a dynamic driving simulator with the same motion cues as would occur in reality. The DLR Driving Simulator, which is the subject matter of this thesis, uses a hexapod motion platform to ...
Weiß, Cornelius
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source