Results 91 to 100 of about 484,206 (263)

Leveraging Explainable Machine Learning to Decipher Ecosystem Health and Nonlinear Dynamics in the Henan Yellow River Basin

Land
Addressing national goals for ecological conservation in the Yellow River Basin, this study focuses on its Henan segment (HYRB). We developed a VOR-SQ assessment framework by augmenting the classic Vitality–Organization–Resilience model with ecosystem ...
Yuhui Cheng, Xiwang Zhang, Shiqi Yu, Yang Liu, Jinli Hu, Yuanyuan Jiang, Chengqiang Zhang, Xinran Wu   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Spatial–Temporal Differentiation and Driving Factors of Cultivated Land Use Transition in Sino–Vietnamese Border Areas

Land
Understanding the transformation of cultivated land use is crucial for advancing sustainable development goals related to food security. However, in mountainous regions, there is a lack of comprehensive studies that fully account for the diverse factors ...
Xiaofei Pang, Binggeng Xie, Rucheng Lu, Xuemao Zhang, Jing Xie, Shaoyin Wei   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Coordination and Driving Mechanism of Water-Energy-Food-Ecology Coupling System in Inner-Mongolia Reaches of Yellow River Based on Coupling Coordination Degree Model

Renmin Zhujiang
In order to realize the high quality and sustainable development of the Inner-Mongolia Reaches of Yellow River, this paper took Dalad Banner and its townships as research objects and constructed a water-energy-food-ecology (W-E-F-E) coupling coordination
TAN Hanze, ZHANG Zezhong, FENG Kai, LUO Xudong, ZHOU Quancheng, LIU Yong, ZHANG Dequan   +6 more
doaj  

Dynamic Evolution and Driving Mechanism of a Multi-Agent Green Technology Cooperation Innovation Network: Empirical Evidence Based on Exponential Random Graph Model

Systems
As a crucial vehicle for green technological innovation, cooperative networks significantly promote resource integration and knowledge sharing. Yet, their dynamic evolution and micro-mechanism remain underexplored.
Jing Ma, Lihua Wu, Jingxuan Hu
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Remote sensing assessment of carbon balance vis-a-vis energy-related emissions and vegetation sequestration in a typical arid region of China from 2001 to 2020

International Journal of Digital Earth
Since 2000, the Western Development Strategy and warming-humidification of Northwest China have led to notable changes in Xinjiang’s carbon emissions and sequestration. Understanding the regional carbon budget is key to sustainable development.
Xin He, Fei Zhang, Ting Zhou, Chi Yung Jim, Xu Ma, Boyu Wang, Mou Leong Tan, Lifei Wei, Yuxin Zhang, Xuan Zhang   +9 more
doaj   +1 more source