Results 61 to 70 of about 4,356,687 (302)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Characterizing Visual Attention during Driving and Non-driving Hazard Perception Tasks [PDF]

, 2014
Funding: EPSRC DTGResearch into driving skill, particularly of hazard perception, often involves studies where participants either view pictures of driving scenarios or use movie viewing paradigms.
Andrew K. Mackenzie, Harris, Julie, MacKenzie, Andrew Kerr, Julie M. Harris, Harris, Julie; id_orcid   +4 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Identifying Trade-Offs and Synergies of Production–Living–Ecological Functions and Their Drivers: The Case of Yangtze River Urban Agglomerations in China

Land
Urban agglomerations are products of urban development, and their regional spaces and functions are more diverse than other cities, which have very high spatial and functional complexity.
Liang Zheng, Yajing Wang, Hui Yang, Yuzhe Bi, Lei Xu, Ying Wang   +5 more
doaj   +1 more source

Circadian clock mechanism driving mammalian photoperiodism

Nature Communications, 2020
“Life in a seasonal environment requires appropriate timing of physiological changes to survive, but how the circadian clockwork times these changes remains unclear.
S. H. Wood, M. M. Hindle, Y. Mizoro, Y. Cheng, B. R. C. Saer, K. Miedzinska, H. C. Christian, N. Begley, J. McNeilly, A. S. McNeilly, S. L. Meddle, D. W. Burt, A. S. I. Loudon   +12 more
doaj   +1 more source

Teen safe driving in Connecticut

, 2011
Annual; "Annual Report on Effectiveness of Connecticut's Teen Driving Laws."; Harvested from the web on 8/18 ...

core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

A LINEAR DRIVING MECHANISM APPLIED TO CAPSULE ROBOTS

, 2009
The article presents a helpful trial on the design of capsule robots' actuators. A harmless, controllable driving mechanism is proved promising both by finite element analysis and by experiments in reality. In brief, the distinct actuator has obvious
Tan RJ(谭人嘉), Zhang C(张诚), Li HY(李洪谊), Su G(苏刚)   +3 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source