Results 41 to 50 of about 3,434,986 (241)

A randomized control trial evaluating the advice of a physiological-model/digital twin-based decision support system on mechanical ventilation in patients with acute respiratory distress syndrome

Frontiers in Medicine
BackgroundAcute respiratory distress syndrome (ARDS) is highly heterogeneous, both in its clinical presentation and in the patient’s physiological responses to changes in mechanical ventilator settings, such as PEEP.
Brijesh V. Patel, Brijesh V. Patel, Sharon Mumby, Nicholas Johnson, Rhodri Handslip, Sunil Patel, Teresa Lee, Martin S. Andersen, Emanuela Falaschetti, Ian M. Adcock, Danny F. McAuley, Masao Takata, Thomas Staudinger, Dan S. Karbing, Matthieu Jabaudon, Peter Schellongowski, Stephen E. Rees, On behalf of the DeVENT Study Group   +17 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Interpretation and use of intraoperative protective ventilation parameters: a scoping review

Anaesthesiology Intensive Therapy, 2022
Thirty years ago, the traditional approach to mechanical ventilation consisted of the normalization of PaCO2 and pH at the expense of using a tidal volume (VT) of 10–15 mL kg-1.
Alejandro Placenti, Franco Fratebianchi
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Other title: Teen safe driving in Connecticut

, 2014
Annual; "Annual Report on Effectiveness of Connecticut's Teen Driving Laws.

core   +1 more source

Positive End-Expiratory Pressure and Respiratory Rate Modify the Association of Mechanical Power and Driving Pressure With Mortality Among Patients With Acute Respiratory Distress Syndrome

Critical Care Explorations, 2021
IMPORTANCE:. Mechanical power and driving pressure have known associations with survival for patients with acute respiratory distress syndrome. OBJECTIVES:.
Joseph E. Tonna, MD, MS, Ithan D. Peltan, MD, MSc, Samuel M. Brown, MD, MS, Colin K. Grissom, MD, Angela P. Presson, PhD, Jennifer S. Herrick, MS, Francesco Vasques, MD, Heather T. Keenan, MDCM, PhD   +7 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Other title: Teen safe driving in Connecticut

, 2015
Annual; "Annual Report on Effectiveness of Connecticut's Teen Driving Laws.

core   +1 more source