Results 81 to 90 of about 3,434,986 (241)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Teen safe driving in Connecticut
, 2011 Annual; "Annual Report on Effectiveness of Connecticut's Teen Driving Laws."; Harvested from the web on 8/18 ...
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Glance behaviours when using an in-vehicle smart driving aid : a real-world, on-road driving study [PDF]
, 2014 In-vehicle information systems (IVIS) are commonplace in modern vehicles, from the initial satellite navigation and in-car infotainment systems, to the more recent driving related Smartphone applications.
Fowkes, Mark, Birrell, Stewart A.
core +1 more source
Bus driving behaviour and fuel consumption
, 2012 The behaviour of driver is influenced by many factors, which include the personal characteristics (attitude, experience etc.) environmental (road geometry, traffic control etc.) and vehicle characteristics (performance, load etc.).
Rohani, Munzilah
core +1 more source
Türk Yoğun Bakim Derneği DergisiObjective: Respiratory failure is one of the most common causes of mortality in pediatric intensive care unit (PICU) patients. Adult and a small number of pediatric studies have also associated driving pressure with mortality in ARDS patients, but ...
Ekin Soydan +9 more
doaj +1 more source
Driving pressure during proportional assist ventilation: an observational study
Annals of Intensive Care, 2019 Background During passive mechanical ventilation, the driving pressure of the respiratory system is an important mediator of ventilator-induced lung injury.
Katerina Vaporidi +9 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source