Results 71 to 80 of about 3,434,986 (241)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Advances in Imaging and Physiology-Guided Personalized Care in Acute Respiratory Distress Syndrome

Medicina
Acute respiratory distress syndrome (ARDS) is a heterogeneous inflammatory lung injury marked by increased alveolar–capillary permeability, reduced respiratory system compliance, and impaired gas exchange.
Lucas Rodrigues Moraes, Pedro Leme Silva, Denise Battaglini, Patricia Rieken Macedo Rocco   +3 more
doaj   +1 more source

Driving pressure: Clinical applications and implications in the intensive care units

Indian Journal of Respiratory Care, 2018
Acute respiratory distress syndrome (ARDS) is considered a frequent and serious lung disease that is continuously linked with an increase in both morbidity and mortality.
Jithin K Sreedharan, Jaber Saud Alqahtani   +1 more
doaj   +1 more source

Airway pressure morphology and respiratory muscle activity during end-inspiratory occlusions in pressure support ventilation

Critical Care, 2020
Background The driving pressure of the respiratory system is a valuable indicator of global lung stress during passive mechanical ventilation. Monitoring lung stress in assisted ventilation is indispensable, but achieving passive conditions in ...
Stella Soundoulounaki, Evangelia Akoumianaki, Eumorfia Kondili, Emmanouil Pediaditis, Georgios Prinianakis, Katerina Vaporidi, Dimitris Georgopoulos   +6 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Driving Pressure-Guided Ventilation in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy: A Randomized Controlled Trial

Diabetes, Metabolic Syndrome and Obesity, 2023
Guanyu Yang,* Pin Zhang,* Liumei Li, Jingjing Wang, Pengfei Jiao, Jie Wang, Qinjun Chu Department of Anesthesiology and Perioperative Medicine, Zhengzhou Central Hospital, Zhengzhou, Henan, People’s Republic of China*These authors contributed
Yang G, Zhang P, Li L, Wang J, Jiao P, Wang J, Chu Q   +6 more
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Other title: Teen safe driving in Connecticut

, 2012
Annual; "Annual Report on Effectiveness of Connecticut's Teen Driving Laws.

core  

Self-Reported Upper Body Discomfort due to Driving: Effect of Driving Experience, Gender and Automobile Age [PDF]

, 2005
This study investigated the human upper body discomfort caused by automobile driving. Both global and local discomfort estimates were achieved by means of a self-administered questionnaire.
Giacomin, J
core   +4 more sources

Intraoperative Driving Pressure and Postoperative Pulmonary Complications Following Cardiac Surgery: A Prospective Observational Study

Medicina
Background and Objectives: Postoperative pulmonary complications (PPCs) remain an important cause of morbidity after cardiac surgery. Driving pressure (DP), defined as the difference between plateau pressure and positive end-expiratory pressure, has been
Canan Yılmaz, Filiz Ata, Selimcan Yırtımcı, Eralp Çevikkalp, Emre Ulusoy, Ümran Karaca, Ayşe Neslihan Balkaya, Tuğba Onur, Abdulkadir İskender, Mehmet Gamlı   +9 more
doaj   +1 more source